重组人 LRP1 蛋白 (GST tag N-Terminus)

特殊说明

形式

Liquid

附加说明

Glutathione Sepharose 4 Fast Flow

常规信息

功能

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed : 11907044, PubMed : 12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed : 1702392, PubMed : 26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed : 32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed : 12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed : 9252371).. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

序列相似性

Belongs to the LDLR family.

翻译后修饰

Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.. The N-terminus is blocked.. Phosphorylated on serine and threonine residues.. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.