AB276229

重组人LAYN蛋白(Fc Chimera)

Name: 重组人LAYN蛋白(Fc Chimera) (ab276229)| Abcam中文官网
Brand: Abcam Limited
SKU: AB276229
Price: 5133 CNY
Availability: InStock

Recombinant Human LAYN protein (Fc Chimera)

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Recombinant Human LAYN protein (Fc Chimera) is a Human Fragment protein, in the 1 to 220 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

UNQ208/PRO234, LAYN, Layilin

1 Images

SDS-PAGE - Recombinant Human LAYN protein (Fc Chimera) (AB276229)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human LAYN protein (Fc Chimera) (AB276229)

SDS-PAGE analysis of ab276229.

关键信息

纯度

>90% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

应用

SDS-PAGE

applications

生物活性

访问

Q6UX15

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 7.5 Constituents: 0.75% Glycine, 0.61% Tris, 0.06% Sodium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"MRPGTALQAVLLAVLLVGLRAATGRLLSGQPVCRGGTQRPCYKVIYFHDTSRRLNFEEAKEACRRDGGQLVSIESEDEQKLIEKFIENLLPSDGDFWIGLRRREEKQSNSTACQDLYAWTDGSISQFRNWYVDEPSCGSEVCVVMYHQPSAPAGIGGPYMFQWNDDRCNMKNNFICKYSDEKPAVPSREAEGEETELTTPVLPEETQEEDAKKTFKESRE","proteinLength":"Fragment","predictedMolecularWeight":"49.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":220,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6UX15","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The LAYN protein also known as layilin plays a role in cell adhesion and signal transduction. It is an approximately 55 kDa protein expressed mainly in epithelial and immune cells including T-cells and natural killer cells. This protein sits on the cell surface and has a connection to the cytoskeleton through its cytoplasmic tail. Alternate expression may occur in both normal and cancerous tissues indicating a role in various physiological and pathological processes.

Biological function summary

LAYN facilitates interactions between cells and the extracellular matrix. It acts as a receptor for hyaluronic acid contributing to cell migration and tissue remodeling. While it is not part of any specific complex layilin may interact with other extracellular matrix proteins to promote cellular activities. This interaction influences immune responses by modulating immune cell activation and homing.

Pathways

LAYN is involved in the hyaluronan-mediated motility pathway where it binds hyaluronic acid to regulate cell movement. Additionally the protein takes part in the immune response pathway by influencing immune cell behavior. LAYN interacts with proteins like moesin which helps connect the cell membrane to the actin cytoskeleton driving cellular changes during these processes.

LAYN has a connection to cancer progression and autoimmune diseases. It plays a role in the tumor microenvironment affecting tumor cell motility and can influence metastasis. In autoimmune disorders LAYN's role in modulating immune cell activity can trigger aberrant immune responses. The protein interacts with various components of the immune system linking its expression to both health and disease states.

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特殊说明

形式

Lyophilized

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常规信息

功能

Receptor for hyaluronate.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Receptor for hyaluronate.

See full target information LAYN

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重组人LAYN蛋白(Fc Chimera)

Recombinant Human LAYN protein (Fc Chimera)

SDS-PAGE - Recombinant Human LAYN protein (Fc Chimera) (AB276229)

关键信息

纯度

内毒素水平

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液