JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB202613

重组人 LAP3 蛋白 (His tag N-Terminus)

Recombinant Human LAP3 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human LAP3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 519 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

LAPEP, PEPS, LAP3, Cytosol aminopeptidase, Cysteinylglycine-S-conjugate dipeptidase, Leucine aminopeptidase 3, Leucyl aminopeptidase, Peptidase S, Proline aminopeptidase, Prolyl aminopeptidase, LAP-3

1 Images
SDS-PAGE - Recombinant Human LAP3 protein (His tag N-Terminus) (AB202613)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human LAP3 protein (His tag N-Terminus) (AB202613)

15% SDS-PAGE analysis of ab202613 (3μg).

关键信息

纯度

>85% SDS-PAGE

ab202613 was purified using conventional chromatography.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P28838

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

storage-buffer

style
left-column

搭配使用产品

Reagents, Controls & Accessories

AB325996

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 12 bands) (AB325996)

  • 0
  • 0
Assay Kits

AB234627

Leucine Aminopeptidase (LAP) Activity Assay Kit (Fluorometric)

Functional Studies - Leucine Aminopeptidase (LAP) Activity Assay Kit (Fluorometric) (AB234627)

  • 0
  • 0
Assay Kits

AB241029

Gamma Glutamyl Transferase (GGT) Assay Kit (Colorimetric)

Functional Studies - Gamma Glutamyl Transferase (GGT) Assay Kit (Colorimetric) (AB241029)

  • 5
  • 1
Proteins & Peptides

AB190382

Recombinant Human GGT1/GGT protein

  • 0
  • 0
Proteins & Peptides

AB80376

Recombinant human Prolyl Endopeptidase protein (His tag N-Terminus)

Functional Studies - Recombinant human Prolyl Endopeptidase protein (His tag N-Terminus) (AB80376)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA","proteinLength":"Full Length","predictedMolecularWeight":"58.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":519,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P28838","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

LAP3 also known as leukotriene A4 hydrolase has a molecular weight of approximately 53 kDa. This enzyme functions as an aminopeptidase which is a type of enzyme that removes amino acids from the amino terminus of proteins and peptides. It is expressed in many tissues with significant levels found in the liver and kidney. LAP3 also shows activity in the cellular cytoplasm indicating it plays a role in cellular metabolic processes.
Biological function summary

LAP3 participates in protein maturation and degradation. It plays a role in processing peptides that are destined for further degradation or cellular signaling. The LAP3 protein is not known to be part of a larger complex but it works alongside other enzymes involved in peptide metabolism. This activity contributes to the regulation of intracellular peptide concentrations and supports cellular homeostasis.

Pathways

LAP3 is linked to important biological processes such as protein catabolism and the regulation of blood pressure. It interacts within the peptide processing pathways to influence the generation of bioactive peptides. LAP3 works in conjunction with other proteolytic enzymes such as aminopeptidases and endopeptidases which are essential for various cellular functions. Through these pathways LAP3 indirectly impacts the regulation of physiological processes.

LAP3 is associated with hypertension and certain metabolic disorders. It influences conditions like high blood pressure through its role in generating peptides that can modulate vascular functions. LAP3 has connections with proteins involved in these conditions such as angiotensin-converting enzyme (ACE) which also plays a part in blood pressure regulation. Understanding the functions of LAP3 aids in delineating its potential as a therapeutic target for these diseases.
style
left-column

常规信息

功能

Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.

序列相似性

Belongs to the peptidase M17 family.

style
left-column

产品实验方案

style
left-column

靶点信息

Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.
See full target information LAP3
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Liver cancer 12:590-602 PubMed38058421

2023

Real-Time Fluorescence Imaging to Identify Cholangiocarcinoma in the Extrahepatic Biliary Tree Using an Enzyme-Activatable Probe.

Applications

Unspecified application

Species

Unspecified reactive species

Ryugen Takahashi,Takeaki Ishizawa,Yoshinori Inagaki,Mariko Tanaka,Akira Ogasawara,Yugo Kuriki,Kyohhei Fujita,Mako Kamiya,Tetsuo Ushiku,Yasuteru Urano,Kiyoshi Hasegawa
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com