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AB160141

重组人 Keratin 36 蛋白 (GST tag N-Terminus)

Recombinant Human Keratin 36 protein (GST tag N-Terminus)

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Recombinant Human Keratin 36 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 417 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

HHA6, HKA6, KRTHA6, KRT36, Keratin-36, K36

1 Images
SDS-PAGE - Recombinant Human Keratin 36 protein (GST tag N-Terminus) (AB160141)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Keratin 36 protein (GST tag N-Terminus) (AB160141)

ab160141 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

O76013

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MLRSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":417,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O76013","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Keratin 36 also known as KRT36 or K6HF is a type I keratin protein within the keratin family. The protein has a mass of approximately 50 kDa. This protein primarily expresses in hair follicles particularly in the inner root sheath and the hair shaft cortex. Keratin 36 contributes to the mechanical stability and integrity of hair fibers assisting in forming and maintaining the strength and resilience of the hair structure.
Biological function summary

Keratin 36 serves an important role in the structural framework of epithelial cells specifically those contributing to keratinocyte function and hair formation. It forms intermediate filaments as part of a larger keratin complex interacting with other keratins such as type II hard keratins in hair and nails. These interactions help establish the strong and insoluble nature of the protective barriers where keratin is present.

Pathways

Keratin 36 participates in intricate signaling related to hair follicle morphogenesis and differentiation. It is involved in the epithelial structural complex working alongside pathways such as the Wnt signaling pathway and the epidermal growth factor (EGF) signaling pathway. Related proteins like Keratin 35 and Keratin 85 also play essential roles in these pathways further integrating with the processes governing hair and skin tissue formation.

Keratin 36 mutations or dysregulation link to conditions like hair disorders and keratoderma. Specifically hereditary conditions such as monilethrix characterized by brittle beaded hair show associations with alterations in keratin expression patterns. Keratin 36 interacts with proteins like Filaggrin and Loricrin in these contexts which are also involved in related structural disorders of the skin.
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特殊说明

形式

Liquid

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常规信息

序列相似性

Belongs to the intermediate filament family.

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产品实验方案

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靶点信息

See full target information KRT36
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搭配使用产品

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