重组人KCNV2蛋白(ab127468)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% Purified via His tag
- Tags: His-DHFR tag N-Terminus
- Suitable for: SDS-PAGE
描述
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产品名称
重组人KCNV2蛋白 -
纯度
> 95 % Purified via His tag.
Purity is >95% by SDS-PAGE. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Protein fragment -
无动物成分
No -
性质
Recombinant -
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种属
Human -
预测分子量
16 kDa -
氨基酸
12 to 154 -
标签
His-DHFR tag N-Terminus
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab127468 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
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形式
Lyophilized -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at -20ºC.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride
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复溶Reconstitute with water to desired concentration.
常规信息
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别名
- KCNV2
- KCNV2_HUMAN
- KV11.1
see all -
功能
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. -
组织特异性
Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon. -
疾病相关
Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B) [MIM:610356]; also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. -
序列相似性
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily. -
结构域
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
细胞定位
Cell membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab127468 尚未被引用在任何文献中。