JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB132771

重组人 KAR 蛋白 (GST tag N-Terminus)

Recombinant Human KAR protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human KAR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 98 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

SDR12C1, HSD17B12, Very-long-chain 3-oxoacyl-CoA reductase, 17-beta-hydroxysteroid dehydrogenase 12, 3-ketoacyl-CoA reductase, Estradiol 17-beta-dehydrogenase 12, Short chain dehydrogenase/reductase family 12C member 1, 17-beta-HSD 12, KAR

1 Images
SDS-PAGE - Recombinant Human KAR protein (GST tag N-Terminus) (AB132771)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human KAR protein (GST tag N-Terminus) (AB132771)

12.5% SDS-PAGE analysis of ab132771 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, SDS-PAGE, WB

applications

生物活性

No

访问

Q53GQ0

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

搭配使用产品

Primary Antibodies

AB236990

Anti-KAR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAR antibody (AB236990)

  • 0
  • 0
Proteins & Peptides

AB124548

Recombinant Human HP1 gamma/CBX3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human HP1 gamma/CBX3 protein (His tag N-Terminus) (AB124548)

  • 0
  • 0
Proteins & Peptides

AB235969

Recombinant Human SEPP1 protein (His tag)

SDS-PAGE - Recombinant Human SEPP1 protein (His tag) (AB235969)

  • 0
  • 0
Proteins & Peptides

AB152996

Recombinant Human Serine Palmitoyltransferase protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Serine Palmitoyltransferase protein (GST tag N-Terminus) (AB152996)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

This product was previously labelled as HSD17B12.
style
left-column

序列信息

[{"linker":null,"sequence":"MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEISNYT","proteinLength":"Full Length","predictedMolecularWeight":"36.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":98,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q53GQ0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Proprietary technique
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Kainate receptors (KARs) are ionotropic receptors important for fast excitatory neurotransmission. They are also known as 'kainate-type glutamate receptors' and are part of the larger glutamate receptor family. The typical mass of these receptors can vary due to different subunits but they usually range between 100 and 120 kDa. KARs express in the central nervous system especially in regions such as the hippocampus and cortex. They involve in synaptic transmission and plasticity through their role as ligand-gated ion channels.
Biological function summary

KARs participate in mediating excitatory synaptic transmission and are part of a complex with other ion channels and receptors like AMPA and NMDA receptors. They regulate synaptic strength and plasticity which are important for learning and memory processes. Active in both pre- and postsynaptic sites KARs can either enhance or inhibit neurotransmitter release affecting neuronal excitability. Their ability to modulate other neurotransmitter systems highlights their diverse influence on neural circuits.

Pathways

KARs are critical components in the glutamatergic signaling pathway which includes AMPA and NMDA receptors as well. They work closely with these proteins to regulate synaptic plasticity and excitatory neurotransmission. Investigations show the involvement of KARs in the long-term potentiation pathway important for memory encoding. Additionally they overlap with metabotropic glutamate receptors influencing intracellular signaling cascades and calcium dynamics.

KARs have associations with epilepsy and neurodegenerative diseases like Alzheimer’s disease. Dysfunctional KAR signaling can lead to altered neuronal excitability contributing to epilepsy pathogenesis. Moreover in Alzheimer's altered glutamatergic transmission due to impaired KAR function associates with memory deficits. Their connection with AMPA and NMDA receptors is significant here as these proteins also pertain to synaptic dysfunction and cognitive impairments observed in these conditions.
style
left-column

常规信息

功能

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

序列相似性

Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

style
left-column

产品实验方案

style
left-column

靶点信息

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
See full target information HSD17B12
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com