AB59954

重组人 IRF2 蛋白 (His tag N-Terminus)

Name: 重组人IRF2蛋白 (ab59954)| Abcam中文官网
Brand: Abcam Limited
SKU: AB59954
Price: 3228 CNY
Availability: InStock

Recombinant Human IRF2 protein (His tag N-Terminus)

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Recombinant Human IRF2 protein (His tag N-Terminus) is a Human Fragment protein, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

查看别名

Interferon regulatory factor 2, IRF-2, IRF2

1 Images

SDS-PAGE - Recombinant Human IRF2 protein (His tag N-Terminus) (AB59954)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IRF2 protein (His tag N-Terminus) (AB59954)

ab59954 on 15%SDS-PAGE (3µg)

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

应用

SDS-PAGE

applications

生物活性

访问

P14316

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.242% Tris, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLP","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P14316","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Interferon Regulatory Factor 2 (IRF2) also known as IRF-2 plays an important role in cellular processes like modulation of immune responses and regulation of gene expression. It has a molecular mass of approximately 39 kDa. IRF2 is expressed across various tissues including the immune system cells fibroblasts and epithelial cells. It can function as both a transcriptional activator and repressor depending on the context and specific gene targets.

Biological function summary

IRF2 regulates immune responses by controlling the expression of interferon (IFN) responsive genes. It acts independently and as part of transcriptional complexes binding to specific DNA sequences within target genes. Its action prevents excessive activation of immune responses maintaining a balanced immune system. IRF2 also influences cell cycle regulation contributing to its role in cell growth and differentiation.

Pathways

And several cellular communication networks IRF2 is a central figure in the interferon signaling pathway interacting with other members of the IRF family like IRF1 and IRF3. These interactions help propagate signals necessary for effective immune responses. In conjunction with the JAK-STAT pathway IRF2 modulates expressions that control antiviral responses and cellular proliferation showing its critical placement in immune response regulation.

IRF2's dysregulation has associations with cancer and autoimmune diseases. Overexpression of IRF2 is linked to certain cancers providing cells with growth advantages and resistance to apoptosis commonly in concert with proteins like STAT1. In autoimmune diseases IRF2 impacts inflammatory responses with aberrant regulation contributing to conditions like systemic lupus erythematosus. Its involvement highlights the complex nature of immune regulation and potential for targeted therapy interventions.

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特殊说明

形式

Liquid

附加说明

using conventional chromatography techniques.

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常规信息

功能

DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed : 39013473, PubMed : 7687740). Mainly acts as a transcription repressor, repressing expression (PubMed : 39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed : 15226432, PubMed : 9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed : 15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed : 9540062). Antagonizes IRF1 transcriptional activation (By similarity).. Isoform 2. Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression.

序列相似性

Belongs to the IRF family.

翻译后修饰

Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.. The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.

亚细胞定位

Nucleus

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information IRF2

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重组人 IRF2 蛋白 (His tag N-Terminus)

Recombinant Human IRF2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human IRF2 protein (His tag N-Terminus) (AB59954)

关键信息

纯度

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液