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AB63177

重组人IPL-1/STK13/Aurora C蛋白

Recombinant human IPL-1/STK13/Aurora C protein

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Recombinant human IPL-1/STK13/Aurora C protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.

查看别名

AIE2, AIK3, AIRK3, ARK3, STK13, AURKC, Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, ARK-3, Aurora-related kinase 3

4 Images
Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
  • FuncS

Unknown

Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)

The specific activity of IPL-1/STK13/Aurora C (ab63177) was determined to be 65 nmol/min/mg as per activity assay protocol

Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
  • FuncS

Unknown

Functional Studies - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)

Kinase activity plot

SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)

SDS PAGE analysis of ab63177

SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human IPL-1/STK13/Aurora C protein (AB63177)

ab63177 on SDS-PAGE, MW ~61 kDa

关键信息

纯度

>80% Densitometry

表达系统

Baculovirus infected Sf9 cells

标签

Tag free

应用

FuncS, SDS-PAGE

applications

生物活性

Yes

生物学活性

Specific activity 65nmol/min/mg

访问

Q9UQB9

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA, 0.00174% PMSF

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Kinase assay.</p>" } } }
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产品详情

ab43614 (Human Myelin Basic Protein full length protein) can be utilized as a substrate for assessing Kinase activity
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序列信息

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9UQB9","tags":[]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
True
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

IPL-1 also known as STK13 or Aurora C is a serine/threonine protein kinase with a molecular mass of approximately 39 kDa. It expresses mainly in testis and ovarian tissue playing a significant role in cell division. As a member of the Aurora kinase family IPL-1 functions mechanistically in regulating the centrosome during cell cycle progression ensuring the proper segregation of chromosomes during mitosis and meiosis. The protein undergoes phosphorylation to activate its kinase activity which is essential for its role in chromatin modification and assembly of microtubules.
Biological function summary

IPL-1 functions in chromosomal alignment and cytokinesis during cell division. It forms part of the chromosomal passenger complex (CPC) along with INCENP Survivin and Borealin. This complex is essential for correcting errors in chromosome segregation. IPL-1's activity helps maintain genomic stability by ensuring that cells divide correctly. Given its role in the chromosomal passenger complex IPL-1 is critical in monitoring and controlling the accurate distribution of genetic material between daughter cells.

Pathways

IPL-1 is intricately involved in cellular processes like the mitotic spindle checkpoint and the regulation of the mitotic cell cycle. It interacts with other proteins such as Aurora B which shares similar functions in the mitotic pathway. IPL-1 helps coordinate the activities of these pathways and proteins to ensure orderly cell division. Through these pathways IPL-1 influences the balance of cell proliferation and cell death which is important for normal organismal development and function.

Misregulation of IPL-1 is associated with cancers including ovarian and testicular cancer. Aberrant expression or activation of IPL-1 can lead to chromosomal instability contributing to tumorigenesis. Additionally the overexpression of Aurora kinase family members including IPL-1 often co-occurs with Cyclin B1 dysregulation in cancer cells. The connection between IPL-1 and Cyclin B1 highlights potential therapeutic targets for cancer treatment as researchers continue to explore strategies for inhibiting IPL-1 to restore normal cell cycle control in tumor cells.
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特殊说明

形式

Liquid

附加说明

Affinity purified.

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常规信息

功能

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

序列相似性

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
See full target information AURKC
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搭配使用产品

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