JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB271595

重组人 ILT-4 蛋白 (Biotin) (Avi tag C-Terminus + His tag C-Terminus)

Recombinant Human ILT-4 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human ILT-4 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 22 to 458 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

查看别名

CD85d, ILT4, LIR2, MIR10, LILRB2, Leukocyte immunoglobulin-like receptor subfamily B member 2, LIR-2, Leukocyte immunoglobulin-like receptor 2, CD85 antigen-like family member D, Immunoglobulin-like transcript 4, Monocyte/macrophage immunoglobulin-like receptor 10, ILT-4, MIR-10

1 Images
SDS-PAGE - Recombinant Human ILT-4 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) (AB271595)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ILT-4 protein (Biotin) (Avi tag C-Terminus + His tag C-Terminus) (AB271595)

SDS-PAGE analysis of 4 μg ab271595.

关键信息

纯度

>90% SDS-PAGE

表达系统

HEK 293 cells

标签

Avi tag C-Terminus His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

偶联物

Biotin

激发波长/发射波长
访问

Q8N423

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher molecular weight due to glycosylation.</p>" } } }
style
left-column

产品详情

Enzymatically biotin-labeled using Avi-tag™ technology
style
left-column

序列信息

[{"sequence":"QTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEEEHPQCLNSQPHARGSSRAIFSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGESLTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSECSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAGAADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSGPSMGSSPPPTGPISTPAGPEDQPLTPTGSDPQSGLGRH","proteinLength":"Fragment","predictedMolecularWeight":"52 kDa","actualMolecularWeight":null,"aminoAcidEnd":458,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q8N423","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle|Store in the dark
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ILT-4 also known as Immunoglobulin-like transcript 4 is a transmembrane protein with a molecular weight of approximately 45 kDa. The protein is part of the LILR family and is sometimes referred to as LILRB2 protein. ILT-4 is mainly expressed on myeloid lineage cells including monocytes and dendritic cells. The expression of ILT-4 is important for the modulation of the immune response. Biotinylated ILT-4 and biotinylated LILRB2 versions are used frequently in research to study their interactions and functions.
Biological function summary

ILT-4 plays an important role in the regulation of immune tolerance and inhibition. It is not part of a complex but interacts with other immune regulatory proteins. By binding to MHC class I molecules ILT-4 inhibits the activation of immune responses preventing over-activation and autoimmunity. The ILT-4 protein is critical for helping myeloid cells to maintain a balanced immune response often restricting unnecessary inflammation and promoting tolerance.

Pathways

ILT-4 influences immune signaling pathways such as those that control T cell receptor signaling. ILT-4 interactions with proteins like CD85d and other LILRA6 proteins showcase its involvement in negative regulatory signaling pathways. These pathways are essential for maintaining immune homeostasis and limiting immune-mediated damage during infections or tissue injury.

ILT-4 is implicated in cancer and autoimmune diseases such as multiple sclerosis. In cancers ILT-4 modulates the immune environment allowing tumors to evade immune surveillance. In the context of autoimmune disorders aberrant ILT-4 expression or function can lead to insufficient immune regulation contributing to disease progression. CD85d and LILRB2 proteins are also associated with these conditions further influencing ILT-4's role in disease mechanisms.
style
left-column

特殊说明

形式

Liquid

style
left-column

常规信息

功能

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed : 11169396, PubMed : 12853576, PubMed : 16455647, PubMed : 20448110, PubMed : 27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed : 16455647, PubMed : 20448110, PubMed : 27859042). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed : 11875462, PubMed : 12853576, PubMed : 9548455, PubMed : 9842885).

翻译后修饰

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.

style
left-column

产品实验方案

style
left-column

靶点信息

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed : 11169396, PubMed : 12853576, PubMed : 16455647, PubMed : 20448110, PubMed : 27859042). Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed : 16455647, PubMed : 20448110, PubMed : 27859042). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed : 11875462, PubMed : 12853576, PubMed : 9548455, PubMed : 9842885).
See full target information LILRB2
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB290106

Recombinant Human LILRB1 Protein

SDS-PAGE - Recombinant Human LILRB1 Protein (AB290106)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Assay Kits

AB269551

Human CD85d ELISA Kit (LILRB2)

Recombinant|SimpleStep

Sandwich ELISA - Human CD85d ELISA Kit (LILRB2) (AB269551)

  • 0
  • 0
Primary Antibodies

AB243107

Anti-ILT-4 antibody [EPR22081] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-ILT-4 antibody [EPR22081] - BSA and Azide free (AB243107)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com