重组人IL-37b蛋白
Recombinant Human IL-37b protein
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Recombinant Human IL-37b protein is a Human Fragment protein, in the 46 to 218 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level.
查看别名
FIL1Z, IL1F7, IL1H4, IL1RP1, IL37, Interleukin-37, IL-37, FIL1 zeta, IL-1X, Interleukin-1 family member 7, Interleukin-1 homolog 4, Interleukin-1 zeta, Interleukin-1-related protein, IL-1F7, IL-1H, IL-1H4, IL-1 zeta, IL-1RP1
- HPLC
Supplier Data
HPLC - Recombinant Human IL-37b protein (AB316042)
The purity of Human IL-37b is greater than 90% as determined by SEC-HPLC.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human IL-37b protein (AB316042)
Human IL-37b on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
序列信息
性能和储存信息
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IL-37 functions within the immune response by acting as a critical anti-inflammatory cytokine. It does not form a larger complex for its activity but instead interacts directly with various immune cells. IL-37 is capable of reducing pro-inflammatory cytokine production and dampening the immune response when necessary thereby providing a mechanism to prevent excessive inflammation and tissue damage.
Pathways
IL-37 plays a role in pathways like the inflammatory response and immune regulation. Within these systems it interacts with proteins such as IL-18 and IL-18BP (binding protein) which helps modulate its activity. IL-37 can also influence the NF-kB pathway an essential pathway in regulating the immune response by indirectly reducing inflammation.
特殊说明
形式
Lyophilized
常规信息
功能
Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
序列相似性
Belongs to the IL-1 family.
翻译后修饰
Proteolytically converted to the mature form by CASP1.
亚细胞定位
Nucleus
靶点信息
搭配使用产品
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