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AB310793

重组人IL-24蛋白(His tag)

Recombinant Human IL-24 Protein (His tag)

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Recombinant Human IL-24 Protein (His tag) is a Human Fragment protein, in the 52 to 206 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, Mass Spec.

查看别名

MDA7, ST16, IL24, Interleukin-24, IL-24, Melanoma differentiation-associated gene 7 protein, Suppression of tumorigenicity 16 protein, MDA-7

2 Images
SDS-PAGE - Recombinant Human IL-24 Protein (His tag) (AB310793)
  • SDS-PAGE

Lab

SDS-PAGE - Recombinant Human IL-24 Protein (His tag) (AB310793)

SDS-PAGE analysis of ab310793

HPLC - Recombinant Human IL-24 Protein (His tag) (AB310793)
  • HPLC

Supplier Data

HPLC - Recombinant Human IL-24 Protein (His tag) (AB310793)

HPLC analysis of ab310793

关键信息

纯度

>95% HPLC

内毒素水平

<0.005 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE, Mass Spec, HPLC

applications

生物活性

No

访问

Q13007

不含动物源

Yes

不含载体蛋白

No

种属

Human

复溶

Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80°C for 12 months or +4°C for 1 week. Avoid repeated freeze-thaw.

存储溶液

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"QEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL","proteinLength":"Fragment","predictedMolecularWeight":"19.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":206,"aminoAcidStart":52,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q13007","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
False
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特殊说明

形式

Lyophilized

附加说明

SDS-PAGE>=95%

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常规信息

功能

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).

序列相似性

Belongs to the IL-10 family.

翻译后修饰

Glycosylated.. Ubiquitination at Lys-122 promotes proteasomal degradation.

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产品实验方案

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靶点信息

Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed : 25168428, PubMed : 27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed : 27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed : 11706020, PubMed : 30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed : 25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
See full target information IL24
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搭配使用产品

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