AB158721

重组人 Iduronate 2 sulfatase/SIDS 蛋白 (GST tag N-Terminus)

Name: 重组人Iduronate 2 sulfatase/SIDS蛋白 (ab158721)| Abcam中文官网
Brand: Abcam Limited
SKU: AB158721
Price: 6621 CNY
Availability: InStock

Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus)

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Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 312 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

SIDS, IDS, Iduronate 2-sulfatase, Alpha-L-iduronate sulfate sulfatase, Idursulfase

1 Images

SDS-PAGE - Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus) (AB158721)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus) (AB158721)

ab158721 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

ELISA, WB

applications

生物活性

访问

P22304

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

This product was previously labelled as Iduronate 2 sulfatase.

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序列信息

[{"sequence":"MPPPRTGRGLLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQEDQSSTGFRLKTSSTRKYK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":312,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P22304","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Iduronate 2-sulfatase also known as IDS or iduronate 2-sulfatase protein is an enzyme responsible for hydrolyzing the 2-sulfate groups from the sugar iduronate in glycosaminoglycans (GAGs) such as dermatan sulfate and heparan sulfate. This action is necessary for the lysosomal degradation of GAGs. The IDS protein has a molecular mass of approximately 76 kDa and predominantly resides in lysosomes. It is widely expressed across human tissues but shows higher expression levels in cells involved with significant lysosomal activities.

Biological function summary

IDS functions to ensure proper breakdown and recycling of GAGs preventing their excessive accumulation. Although IDS acts independently its proper functioning complements other enzymes within the lysosomal degradation system. This lysosomal catabolic activity helps maintain cellular homeostasis as GAGs need controlled degradation for effective cell and tissue functions.

Pathways

IDS plays an important role in the lysosomal degradation pathway. By participating in the catabolism of GAGs IDS works alongside other enzymes such as alpha-L-iduronidase. This interaction is part of the larger lysosomal storage and cellular turnover pathways. These pathways are essential for cellular regulation and help prevent the buildup of undegraded molecules that can disrupt cellular functions.

Faulty IDS activity leads to mucopolysaccharidosis type II also known as Hunter syndrome. This disorder arises from defective GAG breakdown resulting in their accumulation causing various systemic symptoms. IDS is closely related to other lysosomal storage disorder proteins like arylsulfatase B as both enzymes collaborate in GAG degradation. Proper comprehension of IDS and its functioning aids in understanding therapeutic approaches to managing associated disorders.

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特殊说明

形式

Liquid

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常规信息

功能

Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.

序列相似性

Belongs to the sulfatase family.

翻译后修饰

Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide.. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

亚细胞定位

Lysosome

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.

See full target information IDS

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重组人 Iduronate 2 sulfatase/SIDS 蛋白 (GST tag N-Terminus)

Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Iduronate 2 sulfatase/SIDS protein (GST tag N-Terminus) (AB158721)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液