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AB216237

重组人 ICOS Ligand/ICOSL 蛋白 (Fc tag C-Terminus)

Recombinant Human ICOS Ligand/ICOSL protein (Fc tag C-Terminus)

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Recombinant Human ICOS Ligand/ICOSL protein (Fc tag C-Terminus) is a Human Fragment protein, in the 19 to 258 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

查看别名

CD275, B7H2, B7RP1, ICOSL, KIAA0653, ICOSLG, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, B7-H2, B7RP-1

1 Images
SDS-PAGE - Recombinant Human ICOS Ligand/ICOSL protein (Fc tag C-Terminus) (AB216237)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ICOS Ligand/ICOSL protein (Fc tag C-Terminus) (AB216237)

SDS-PAGE : 4-20% gel

Lane 1 : 3μg ab216237

Lane 2 : Protein Marker

Coomassie staining used

关键信息

纯度

>90% SDS-PAGE

表达系统

HEK 293 cells

标签

Fc tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

O75144

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride

storage-buffer

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搭配使用产品

Primary Antibodies

AB209262

Anti-ICOS Ligand/ICOSL antibody [EPR20240]

RabMAb|Recombinant|Trial Size

Immunoprecipitation - Anti-ICOS Ligand/ICOSL antibody [EPR20240] (AB209262)

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Proteins & Peptides

AB161322

Recombinant Human HHLA2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human HHLA2 protein (GST tag N-Terminus) (AB161322)

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Proteins & Peptides

AB283481

Recombinant Human PD-L2 protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant Human PD-L2 protein (Active) (AB283481)

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Proteins & Peptides

AB163782

Recombinant Human VISTA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VISTA protein (GST tag N-Terminus) (AB163782)

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  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher MW by SDS-PAGE due to glycosylation.</p>" } } }
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产品详情

Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.

This product was previously labelled as ICOS Ligand

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序列信息

[{"linker":null,"sequence":"DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWS","proteinLength":"Fragment","predictedMolecularWeight":"53.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":258,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O75144","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The ICOS Ligand also known as ICOSL B7-H2 and HK53 is a critical component in immune system function. This protein with a molecular mass of approximately 65 kDa is expressed on professional antigen-presenting cells such as dendritic cells macrophages and B cells. It plays a significant mechanical role in the immune response by engaging with its counter receptor the ICOS protein present on the surface of activated T cells. This interaction supports the regulation of T cell activity influencing proliferation and cytokine production.
Biological function summary

ICOSL contributes to the modulation of immune responses. By forming a complex with the active ICOS protein ICOSL is involved in the co-stimulation of T cells. This process is important for the development of T-cell-dependent immune responses and helps in promoting the survival and differentiation of T cells. Together the ICOS ligand and ICOS protein create a dynamic interaction that balances immune activation and tolerance which is essential for maintaining immune homeostasis.

Pathways

The ICOS-ICOSL interaction plays an important role in the T-cell receptor (TCR) signaling pathway. This pathway is fundamental for the activation of T cells and subsequent immune response. ICOSL also connects to the PI3K/Akt pathway where it impacts cell survival and proliferation. ICOS and the PI3K/Akt pathway work together to influence various aspects of immune regulation and adaptive immunity.

ICOSL has a notable impact on autoimmune diseases and cancer. Its function in immune modulation when dysregulated can contribute to autoimmune conditions such as systemic lupus erythematosus. In this context the abnormal activation of the ICOS protein may exaggerate immune responses leading to pathology. In cancer high expression of ICOSL can support tumor progression by affecting the immune surveillance capability. These associations reveal ICOSL’s role in balancing immune activation and inhibition which is important in the context of disease.
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常规信息

功能

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed : 11007762, PubMed : 11023515, PubMed : 30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed : 30498080).

序列相似性

Belongs to the immunoglobulin superfamily. BTN/MOG family.

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产品实验方案

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靶点信息

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed : 11007762, PubMed : 11023515, PubMed : 30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed : 30498080).
See full target information ICOSLG
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