重组人 HMGA1a / HMGA1b 蛋白 (His tag C-Terminus)

特殊说明

形式

Liquid

附加说明

ab109927 is purified using conventional chromatography techniques.

常规信息

功能

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

序列相似性

Belongs to the HMGA family.

翻译后修饰

Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.. HMG-Y is not methylated.. Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.

亚细胞定位

Nucleus