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AB198676

重组人 Histone H1 蛋白 (His tag N-Terminus)

Recombinant Human Histone H1 protein (His tag N-Terminus)

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(7 Publications)

Recombinant Human Histone H1 protein (His tag N-Terminus) is a Human Full Length protein, in the 2 to 194 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

H1F0, H1FV, H1-0, Histone H1.0, Histone H1', Histone H1(0)

1 Images
SDS-PAGE - Recombinant Human Histone H1 protein (His tag N-Terminus) (AB198676)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Histone H1 protein (His tag N-Terminus) (AB198676)

4-20% SDS-PAGE analysis of ab198676 (2 μg) with Coomassie staining.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P07305

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% Potassium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Useful as a substrate for histone methyltransferase and acetyltransferase assays. Ideal for screening small molecular inhibitors of histone modifying enzymes for drug discovery and HTS applications.
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序列信息

[{"sequence":"MHHHHHHTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK","proteinLength":"Full Length","predictedMolecularWeight":"22 kDa","actualMolecularWeight":null,"aminoAcidEnd":194,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P07305","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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特殊说明

形式

Liquid

附加说明

Affinity purified.

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常规信息

功能

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed : 33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed : 33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed : 7374750).

序列相似性

Belongs to the histone H1/H5 family.

翻译后修饰

Phosphorylated on Ser-17 in RNA edited version.. ADP-ribosylated on Ser-104 in response to DNA damage.

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产品实验方案

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靶点信息

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed : 33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed : 33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed : 7374750).
See full target information H1-0
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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Acta pharmaceutica Sinica. B 15:1608-1625 PubMed40370560

2025

CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuncheng Bei,Sijie Wang,Rui Wang,Owais Ahmad,Meng Jia,Pengju Yao,Jianguo Ji,Pingping Shen

Life science alliance 5: PubMed35173014

2022

Quantitative profiling of adaptation to cyclin E overproduction.

Applications

Unspecified application

Species

Unspecified reactive species

Juanita C Limas,Amiee N Littlejohn,Amy M House,Katarzyna M Kedziora,Brandon L Mouery,Boyang Ma,Dalia Fleifel,Andrea Walens,Maria M Aleman,Daniel Dominguez,Jeanette Gowen Cook

Molecular cell 82:106-122.e9 PubMed34875212

2021

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity.

Applications

Unspecified application

Species

Unspecified reactive species

Daoud Sheban,Tom Shani,Roey Maor,Alejandro Aguilera-Castrejon,Nofar Mor,Bernardo Oldak,Merav D Shmueli,Avital Eisenberg-Lerner,Jonathan Bayerl,Jakob Hebert,Sergey Viukov,Guoyun Chen,Assaf Kacen,Vladislav Krupalnik,Valeriya Chugaeva,Shadi Tarazi,Alejandra Rodríguez-delaRosa,Mirie Zerbib,Adi Ulman,Solaiman Masarwi,Meital Kupervaser,Yishai Levin,Efrat Shema,Yael David,Noa Novershtern,Jacob H Hanna,Yifat Merbl

Nucleic acids research 49:2450-2459 PubMed33733652

2021

Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.

Applications

Unspecified application

Species

Unspecified reactive species

Charles E Deckard,Jonathan T Sczepanski

Cell reports 29:1469-1481.e9 PubMed31693889

2019

NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Bury,Benjamin Le Calvé,Frédéric Lessard,Thomas Dal Maso,James Saliba,Carine Michiels,Gerardo Ferbeyre,Volker Blank

Nucleic acids research 47:7418-7429 PubMed31127309

2019

Restriction of AID activity and somatic hypermutation by PARP-1.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Tepper,Oliver Mortusewicz,Ewelina Członka,Amanda Bello,Angelika Schmidt,Julia Jeschke,Arthur Fischbach,Ines Pfeil,Svend K Petersen-Mahrt,Aswin Mangerich,Thomas Helleday,Heinrich Leonhardt,Berit Jungnickel

Nature communications 9:1876 PubMed29760377

2018

Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Tingjun Lei,Peixuan Zhang,Xudong Zhang,Xue Xiao,Jingli Zhang,Tong Qiu,Qian Dai,Yujun Zhang,Ling Min,Qian Li,Rutie Yin,Ping Ding,Ni Li,Yi Qu,Dezhi Mu,Jun Qin,Xiaofeng Zhu,Zhi-Xiong Xiao,Qintong Li
View all publications
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搭配使用产品

Reagents, Controls & Accessories

AB116027

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB116027)

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Primary Antibodies

AB1791

Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade

Lab Essentials

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Proteins & Peptides

AB198115

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SDS-PAGE - Recombinant Human Histone H4 protein (His tag N-Terminus) (AB198115)

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Proteins & Peptides

AB200295

Recombinant Human Histone H2A protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Histone H2A protein (His tag N-Terminus) (AB200295)

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Proteins & Peptides

AB198637

Recombinant Human Histone H2B protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Histone H2B protein (His tag N-Terminus) (AB198637)

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