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AB310795

重组人HBEGF/DRT蛋白

Recombinant Human HBEGF/DRT Protein

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Recombinant Human HBEGF/DRT Protein is a Human Fragment protein, in the 63 to 148 aa range, expressed in HEK 293 cells, with >95%, >0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, Mass Spec.

查看别名

DTR, DTS, HEGFL, HBEGF, Proheparin-binding EGF-like growth factor

3 Images
Mass Spectrometry - Recombinant Human HBEGF/DRT Protein (AB310795)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human HBEGF/DRT Protein (AB310795)

Mass determination by ESI-TOF. Predicted MW is 9786.5 Da (+/-10 Da by ESI-TOF). Observed MW is 9786.19 Da.

SDS-PAGE - Recombinant Human HBEGF/DRT Protein (AB310795)
  • SDS-PAGE

Lab

SDS-PAGE - Recombinant Human HBEGF/DRT Protein (AB310795)

SDS-PAGE analysis of ab310795

HPLC - Recombinant Human HBEGF/DRT Protein (AB310795)
  • HPLC

Supplier Data

HPLC - Recombinant Human HBEGF/DRT Protein (AB310795)

HPLC analysis of ab310795

关键信息

纯度

>95% HPLC

内毒素水平

>0.005 EU/µg

表达系统

HEK 293 cells

标签

Tag free

应用

SDS-PAGE, Mass Spec, HPLC

applications

生物活性

No

访问

Q99075

不含动物源

Yes

不含载体蛋白

No

种属

Human

复溶

Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80°C for 12 months or +4°C for 1 week. Avoid repeated freeze-thaw.

存储溶液

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"DLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSL","proteinLength":"Fragment","predictedMolecularWeight":"9.8 kDa","actualMolecularWeight":"9.79 kDa","aminoAcidEnd":148,"aminoAcidStart":63,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q99075","tags":[]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

HBEGF also known as Heparin-binding EGF-like growth factor or Diphtheria Toxin Receptor (DTR) is a growth factor that binds to EGF receptors with its mass approximately 20 kilodaltons. It is a member of the EGF family. Cells secrete HBEGF and it is expressed in many tissues including the heart kidney and lungs. Its expression often increases during proliferation and differentiation making it an important player in tissue growth and repair.
Biological function summary

HBEGF functions as a mitogen and chemotactic agent which means it stimulates cell division and attracts cells to migrate. As part of the EGF family HBEGF activates the EGFR (epidermal growth factor receptor) signaling cascade. This signaling is essential for processes such as wound healing and development. HBEGF also forms complexes with other ligands and receptors enhancing its biological activity in tissues.

Pathways

HBEGF plays a role in the MAPK/ERK signaling pathway and the PI3K/AKT pathway. Both pathways are significant for regulating cell growth survival and differentiation. HBEGF interacts with other proteins like Ras and PI3K in these pathways. By activating these pathways HBEGF influences cellular responses critical for normal physiological processes and recovery mechanisms in cells.

HBEGF has connections with cancer and cardiovascular diseases. Aberrant HBEGF signaling can promote oncogenic processes in cancer relating it to proteins such as HER2 which also engage in similar pathways. In cardiovascular diseases HBEGF overexpression can contribute to smooth muscle cell proliferation an important event in atherosclerosis linking it to other growth factors involved in vascular biology.
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特殊说明

形式

Lyophilized

附加说明

SDS-PAGE>=95%

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常规信息

功能

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

翻译后修饰

Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.. O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.

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产品实验方案

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靶点信息

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
See full target information HBEGF
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搭配使用产品

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Proteins & Peptides

AB243239

Recombinant mouse Prolactin/PRL protein (Active)

Bioactive

SDS-PAGE - Recombinant mouse Prolactin/PRL protein (Active) (AB243239)

  • 0
  • 0
Proteins & Peptides

AB285462

Recombinant human FGF2 protein (Active)

Bioactive

Functional Studies - Recombinant human FGF2 protein (Active) (AB285462)

  • 0
  • 0
Primary Antibodies

AB218019

Anti-HBEGF/DTR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HBEGF/DTR antibody (AB218019)

  • 0
  • 0

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