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AB128441

重组人 GSTM5 蛋白 (His tag N-Terminus)

Recombinant Human GSTM5 protein (His tag N-Terminus)

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Recombinant Human GSTM5 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 218 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5, GSTM5

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SDS-PAGE - Recombinant Human GSTM5 protein (His tag N-Terminus) (AB128441)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GSTM5 protein (His tag N-Terminus) (AB128441)

15% SDS-PAGE showing ab128441 (3 µg) at approximately 28.2 kDa.

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

P46439

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLNLKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK","proteinLength":"Full Length","predictedMolecularWeight":"28.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":218,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P46439","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GSTM5 also known as glutathione S-transferase Mu 5 is an enzyme that plays a pivotal role in detoxification processes. GSTM5 has a molecular mass of roughly 26 kDa. This protein belongs to the glutathione S-transferase family which are important for catalyzing the conjugation of glutathione to various substrates. GSTM5 is mainly expressed in tissues like the liver and lungs where detoxification is essential for maintaining cellular health.
Biological function summary

GSTM5 enzymes help in neutralizing toxins and products of oxidative stress by facilitating the conjugation of reduced glutathione to electrophilic compounds. GSTM5 does not function in isolation; it operates as part of the larger GST family that includes various isoforms like GSTM1 and GSTM3 sharing the responsibility of detoxifying harmful chemicals. Through its enzyme activity GSTM5 supports the protection of cells from toxic damage contributing to cellular antioxidant defense.

Pathways

GSTM5 activity contributes to the metabolic pathway involving the detoxification of xenobiotics playing a role in phase II metabolism. It is strongly connected to the glutathione conjugation pathway helping in the clearance of lipid peroxidation products. GSTM5 interacts closely with other proteins in the GST family including GSTP1 pinpointing its role in maintaining cellular redox balance and aiding in the conversion of harmful substances into more water-soluble products for excretion.

GSTM5 is associated with cancer and neurodegenerative diseases. Variations in GSTM5 expression have been linked to increased risk in the development of certain cancers given its role in detoxifying carcinogens. Moreover GSTM5 may influence the progression of neurodegenerative disorders by modulating oxidative stress responses a process where its counterpart GSTP1 also plays a significant part. Understanding GSTM5’s function can offer insights into potential therapeutic approaches for these conditions.
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特殊说明

形式

Liquid

附加说明

ab128441 is purified using conventional chromatography techniques

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常规信息

功能

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

序列相似性

Belongs to the GST superfamily. Mu family.

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产品实验方案

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靶点信息

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
See full target information GSTM5
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搭配使用产品

Primary Antibodies

AB154018

Anti-GSTM5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM5 antibody (AB154018)

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