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AB105621

重组人 GSKIP 蛋白 (His tag N-Terminus)

Recombinant Human GSKIP protein (His tag N-Terminus)

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Recombinant Human GSKIP protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 139 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

C14orf129, HSPC210, GSKIP, GSK3B-interacting protein, GSK3beta interaction protein

1 Images
SDS-PAGE - Recombinant Human GSKIP protein (AB105621)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GSKIP protein (AB105621)

15% SDS-PAGE analysis of ab105621 (3μg)

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9P0R6

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Previously labelled as HSPC210.
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMETDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS","proteinLength":"Full Length","predictedMolecularWeight":"17.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":139,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9P0R6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GSKIP also known as GSK3β-interacting protein plays a role in the signaling pathways by acting as a scaffold for protein interactions. This protein has an approximate mass of 17 kDa. GSKIP is expressed in various tissues including the brain and heart suggesting its broad functional significance in different physiological contexts. Its ability to interact with Glycogen Synthase Kinase 3 (GSK3) and other proteins highlights its involvement in important cellular processes.
Biological function summary

The protein functions as a regulatory adapter anchoring key kinases to their target proteins. It interacts with GSK3β forming a stable complex that influences several signaling pathways. By modulating these interactions GSKIP plays a role in controlling cell growth differentiation and apoptosis. Its capacity to form complexes with other proteins enhances its functional versatility within the cell impacting numerous biological processes.

Pathways

GSKIP exerts a notable influence in the Wnt/β-catenin and Hedgehog signaling pathways. It interacts with GSK3β which is a critical component of these pathways regulating cellular processes like proliferation and development. By affecting the stability and activity of β-catenin GSKIP indirectly influences gene expression. Additionally its involvement in these pathways links it to other related proteins like Axin which help modulate signal transduction.

GSKIP has connections to cancer and neurodegenerative diseases partly due to its role in regulating GSK3β activity. Alterations in the pathways involving GSKIP can impact disease progression and response to treatment. In cancer dysregulation of the Wnt pathway through GSKIP interactions may lead to abnormal cell proliferation. In neurodegenerative diseases its interaction with GSK3β relates to the phosphorylation of tau protein a significant aspect of Alzheimer's disease pathology.
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特殊说明

形式

Liquid

附加说明

ab105621 was purified using conventional chromatography techniques.

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常规信息

功能

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed : 16981698, PubMed : 25920809, PubMed : 27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed : 16981698, PubMed : 27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed : 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed : 19830702).

序列相似性

Belongs to the GSKIP family.

翻译后修饰

Phosphorylated by GSK3B.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed : 16981698, PubMed : 25920809, PubMed : 27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed : 16981698, PubMed : 27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed : 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed : 19830702).
See full target information GSKIP
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