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AB276697

重组人GPR133蛋白(His tag)

Recombinant Human GPR133 protein (His tag)

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Recombinant Human GPR133 protein (His tag) is a Human Fragment protein, in the 1 to 570 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

GPR133, PGR25, ADGRD1, Adhesion G-protein coupled receptor D1, G-protein coupled receptor 133, G-protein coupled receptor PGR25

1 Images
SDS-PAGE - Recombinant Human GPR133 protein (His tag) (AB276697)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GPR133 protein (His tag) (AB276697)

SDS-PAGE analysis of ab276697

关键信息

纯度

>90% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q6QNK2

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: 100% PBS

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDTTGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRPIPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEIAMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYLQNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGHVSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAWSTVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVALSSIS","proteinLength":"Fragment","predictedMolecularWeight":"61.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":570,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6QNK2","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GPR133 also known as ADGRD1 is a member of the adhesion G protein-coupled receptor (GPCR) family. It possesses a large extracellular domain and a characteristic seven-transmembrane domain typical of GPCRs with a molecular mass approximately 100 kDa. GPR133 expresses broadly in the central nervous system and several peripheral tissues including the lung and heart. This pattern of expression suggests its involvement in various physiological functions.
Biological function summary

Adhesion G protein-coupled receptor GPR133 has roles in cellular signaling and communication. It participates in the regulation of processes such as cell adhesion and migration. GPR133 does not act alone; it associates with other proteins to affect physiological functions though it is not strictly part of a larger protein complex. Its broad expression in several tissues indicates its functional versatility.

Pathways

Research links GPR133 to significant signaling pathways like the Wnt signaling pathway and the G-protein signaling pathway. It interacts with the proteins involved in these pathways to modulate their downstream effects impacting cellular processes such as proliferation and differentiation. Partner proteins such as heterotrimeric G proteins directly associate with GPR133 playing roles in the signal transduction processes initiated by this receptor.

GPR133 associates with conditions such as glioblastoma and asthma. It often operates alongside other proteins involved in these conditions such as EGFR in glioblastoma and the IL-4 receptor in asthma. Alterations in the expression or function of GPR133 may contribute to the pathogenesis of these diseases by affecting cell signaling pathways presenting it as a potential therapeutic target for intervention.
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特殊说明

形式

Lyophilized

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常规信息

功能

Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed : 39884271). Also activated by methenolone drug (PubMed : 39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed : 22025619, PubMed : 22575658, PubMed : 35447113, PubMed : 39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed : 39884271).

序列相似性

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

翻译后修饰

Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity (By similarity) (PubMed:34022221, PubMed:35418678, PubMed:35447113). Cleavage takes place early in the secretory pathway before N-glycosylation (PubMed:35418678).

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产品实验方案

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靶点信息

Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed : 39884271). Also activated by methenolone drug (PubMed : 39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed : 39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed : 22025619, PubMed : 22575658, PubMed : 35447113, PubMed : 39884271). Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed : 39884271).
See full target information ADGRD1
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