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AB222962

重组人 GPNMB 蛋白 (His tag C-Terminus)

Recombinant Human GPNMB protein (His tag C-Terminus)

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Recombinant Human GPNMB protein (His tag C-Terminus) is a Human Fragment protein, in the 20 to 474 aa range, expressed in Insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

查看别名

HGFIN, NMB, UNQ1725/PRO9925, GPNMB, Transmembrane glycoprotein NMB, Hematopoietic growth factor inducible neurokinin-1 type

1 Images
SDS-PAGE - Recombinant Human GPNMB protein (His tag) (AB222962)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GPNMB protein (His tag) (AB222962)

15% SDS-PAGE - Recombinant Human GPNMB protein (His tag) (3 μg ab222962).

50-70 KDa under reducing conditions.

关键信息

纯度

>90% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

Insect cells

标签

His tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q14956

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"ADPAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"51.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":474,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Insect cells","accessionNumber":"Q14956","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GPNMB also known as osteoactivin is a type I transmembrane glycoprotein with a molecular mass of approximately 115 kDa. This protein is highly expressed in various tissues including the bone skin and brain. It also shows notable presence in certain immune cells such as dendritic cells and macrophages. GPNMB localizes mainly on the cell membrane and within lysosomal compartments indicating its involvement in cellular and signaling processes.
Biological function summary

GPNMB plays versatile roles in promoting cell growth differentiation and repair. It is involved in processes like tissue regeneration possibly due to its role in cell adhesion and migration. The protein also partakes in osteoclast differentiation and bone resorption therefore linking to skeletal homeostasis. GPNMB forms part of a broader protein complex at the cellular junctions interacting with integrins to mediate its functions.

Pathways

GPNMB features prominently in osteoclastogenesis and melanoma metastasis pathways. It cooperates with RANKL an important protein in bone metabolism by influencing osteoclast differentiation and activation. In the context of melanoma GPNMB's action in pathways may enhance tumor proliferation and invasion possibly interacting with signaling molecules like AKT or ERK although the specifics remain actively researched.

GPNMB has significant links to both osteoarthritis and certain types of cancer particularly breast cancer and melanoma. In osteoarthritis GPNMB expression often increases reflecting involvement in cartilage degradation processes. Its overexpression correlates with tumor progression in melanoma potentially driven by its interaction with integrin β1 which assists in cellular adhesion and migration within the tumor microenvironment.
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特殊说明

形式

Liquid

附加说明

Affinity purified

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常规信息

功能

Could be a melanogenic enzyme.

序列相似性

Belongs to the PMEL/NMB family.

亚细胞定位

Early endosome membrane

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产品实验方案

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靶点信息

Could be a melanogenic enzyme.
See full target information GPNMB
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搭配使用产品

Primary Antibodies

AB235873

Anti-GPNMB antibody [EPR22011-47]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-GPNMB antibody [EPR22011-47] (AB235873)

  • 0
  • 0
Assay Kits

AB193711

Human Osteoactivin ELISA Kit

Sandwich ELISA - Human Osteoactivin ELISA Kit (AB193711)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Assay Kits

AB65300

Cathepsin B Activity Assay Kit (Fluorometric)

Functional Studies - Cathepsin B Activity Assay Kit (Fluorometric) (AB65300)

  • 0
  • 0

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