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AB113595

重组人 GPD1L 蛋白 (His tag N-Terminus)

Recombinant Human GPD1L protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human GPD1L protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 351 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

KIAA0089, GPD1L, Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L

1 Images
SDS-PAGE - Recombinant Human GPD1L protein (His tag N-Terminus) (AB113595)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPD1L protein (His tag N-Terminus) (AB113595)

15% SDS-PAGE analysis of ab113595 (3μg)

关键信息

纯度

>95% SDS-PAGE

ab113595 was purified using conventional chromatography.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q8N335

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB110413

Total OXPHOS Rodent WB Antibody Cocktail

Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

  • 5
  • 18
Assay Kits

AB115102

Histone H3 Acetylation Assay Kit

ELISA - Histone H3 Acetylation Assay Kit (AB115102)

  • 4
  • 2
Primary Antibodies

AB14748

Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-ATP5A antibody [15H4C4] - Mitochondrial Marker (AB14748)

  • 5
  • 27
Primary Antibodies

AB203832

Anti-UQCRC2 antibody [EPR13051]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UQCRC2 antibody [EPR13051] (AB203832)

  • 5
  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT","proteinLength":"Full Length","predictedMolecularWeight":"40.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":351,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N335","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein GPD1L also known as glycerol-3-phosphate dehydrogenase 1-like protein plays an enzymatic role in converting L-glycerol-3-phosphate to dihydroxyacetone phosphate while reducing NAD+ to NADH. Its molecular mass is approximately 39 kDa. GPD1L is expressed in the heart muscle and various other tissues. Its expression levels vary depending on the tissue indicating different roles in various biological environments.
Biological function summary

GPD1L affects several metabolic processes which are essential for cellular energy balance and homeostasis. It does not form a known complex but interacts with cellular components influencing metabolic flux. By acting as part of redox reactions it helps in maintaining the balance of redox states in cells. It also affects ion channels by modulating sodium current density in cardiac tissues which is important for heart function.

Pathways

GPD1L participates in metabolic and signaling pathways. It is integral to the glycerophosphate shuttle pathway helping in transferring reducing equivalents into mitochondria for ATP production. In addition it has a role in cardiac conduction and regulation of ion channels particularly in conjunction with the protein SCN5A which affects sodium ion flow and heart rhythm.

GPD1L is linked to cardiac arrhythmias such as Brugada syndrome. Mutations in the GPD1L gene can disrupt sodium current which is often associated with irregular heartbeats and increased risk of sudden cardiac death. Its relationship with the SCN5A protein is significant as mutations in SCN5A also contribute to similar cardiac conditions by affecting sodium channel function and predisposition to arrhythmias.
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常规信息

功能

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

序列相似性

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

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产品实验方案

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靶点信息

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
See full target information GPD1L
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1582728 PubMed40538846

2025

GPD1L downregulation in colorectal cancer: a novel obesity-related biomarker linking metabolic dysregulation to tumor progression.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Zhu,Huiyuan Li,Hongzhang Liu,Yusheng Wang
View all publications
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