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AB153607

重组人GPCR TGR5蛋白

Recombinant Human GPCR TGR5 protein

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Recombinant Human GPCR TGR5 protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

TGR5, GPBAR1, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids, hBG37, hGPCR19, M-BAR, BG37

1 Images
SDS-PAGE - Recombinant Human GPCR TGR5 protein (AB153607)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPCR TGR5 protein (AB153607)

ab153607 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q8TDU6

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":330,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TDU6","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GPCR TGR5 also known as G protein-coupled bile acid receptor 1 (GPBAR1) is a member of the GPCR superfamily. This receptor weighs approximately 35 kDa and is expressed in various tissues including liver intestine brown adipose tissue and macrophages. It functions as a membrane receptor that binds bile acids which activates downstream signaling pathways influencing metabolic processes.
Biological function summary

GPCR TGR5 plays a role in energy metabolism and the immune response. It does not form part of a larger receptor complex but interacts with different proteins to mediate its effects. Upon activation by bile acids TGR5 stimulates the production of cyclic AMP (cAMP) and regulates the release of various cytokines influencing metabolic rate and promoting anti-inflammatory effects.

Pathways

GPCR TGR5 links to the cAMP signaling pathway and plays a role in the brown adipose tissue activation pathway. It is closely related to proteins like adenylate cyclase which it activates to increase cAMP levels and potentially interacts with nuclear receptors modifying gene expression linked to energy homeostasis and inflammation control.

GPCR TGR5 associates with metabolic disorders such as obesity and type 2 diabetes. Its role in regulating energy expenditure makes it a target for combating obesity where it influences pathways involving protein partners like adenylate cyclase. Additionally its involvement in controlling inflammation connects it to diseases involving immune dysregulation offering potential pathways for therapeutic interventions.
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特殊说明

形式

Liquid

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常规信息

功能

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

序列相似性

Belongs to the G-protein coupled receptor 1 family.

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产品实验方案

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靶点信息

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
See full target information GPBAR1
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Complementary Products

Primary Antibodies

AB72608

Anti-GPCR TGR5 antibody

BOND RX™ Validated

Western blot - Anti-GPCR TGR5 antibody (AB72608)

  • 0
  • 0
Biochemicals

AB142091

TGR5 Receptor Agonist, TGR5 G-protein coupled receptor agonist

Chemical Structure - TGR5 Receptor Agonist, TGR5 G-protein coupled receptor agonist (AB142091)

  • 0
  • 0
Proteins & Peptides

AB235719

Recombinant Human GLP-1 protein (Tagged)

SDS-PAGE - Recombinant Human GLP-1 protein (Tagged) (AB235719)

  • 0
  • 0
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88

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