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AB289759

重组人GPCR GPRC5D蛋白

Recombinant Human GPCR GPRC5D protein

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Recombinant Human GPCR GPRC5D protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

查看别名

G-protein coupled receptor family C group 5 member D, GPRC5D

1 Images
SDS-PAGE - Recombinant Human GPCR GPRC5D protein (AB289759)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GPCR GPRC5D protein (AB289759)

SDS-PAGE analysis of ab289759

关键信息

纯度

>85% SDS-PAGE

表达系统

Cell free

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9NZD1

不含动物源

Yes

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% dodecyl 2-(trimethylazaniumyl)ethyl phosphate

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGMMFVNMTPCQLNVDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRSCRQECPLQGNACPVTAYQHSFQVENQELSRARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV","proteinLength":"Full Length","predictedMolecularWeight":"41.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q9NZD1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPRC5D also known as the GPRC5D protein or by the code 6D9 in certain research contexts is a member of the G-protein-coupled receptors (GPCRs) superfamily. This family acts as a significant mediator of cellular responses to external signals. The GPRC5D has a mass of approximately 56 kDa. It is mainly expressed in the human bone marrow and the keratinocytes of the skin with notable absence in other tissues. It also appears in certain immune cells indicating its potential involvement in immune system responses.
Biological function summary

The role of GPCR GPRC5D centers on cell signaling mechanisms within the immune system. GPCR GPRC5D engages in intracellular signaling cascades that modulate immune functions although it is not known to be part of a larger receptor complex. Its function may involve interactions with molecules that transmit environmental signals into cellular responses enhancing its importance in immune regulation and possibly other cellular functions.

Pathways

GPCR GPRC5D participates in signaling pathways like the immune regulation pathway and the skin development pathway. It relates to proteins such as arrestins which link GPCRs to downstream signaling pathways. This connection hints at a regulatory role in cellular response where GPCR GPRC5D acts as a conduit for signal transduction balancing cellular responses to external stimuli and maintaining cellular homeostasis.

GPCR GPRC5D has associations with multiple myeloma and psoriasis. Its expression in bone marrow links it to multiple myeloma where its level might impact cancer progression. Proteins such as interleukin-17 and others relevant to psoriasis are connected to GPCR GPRC5D through skin-related pathways suggesting its role in inflammatory responses and potential as a therapeutic target for skin disorders. This illustrates GPRC5D's relevance in specific pathological conditions offering avenues for research into targeted treatments.
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特殊说明

形式

Lyophilized

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常规信息

功能

G-protein coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails.

序列相似性

Belongs to the G-protein coupled receptor 3 family.

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产品实验方案

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靶点信息

G-protein coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails.
See full target information GPRC5D
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搭配使用产品

Proteins & Peptides

AB316501

Recombinant Human CD3 Epsilon Protein Standard (His tag)

Sandwich ELISA - Recombinant Human CD3 Epsilon Protein Standard (His tag) (AB316501)

  • 0
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Primary Antibodies

AB315808

Anti-GPCR GPRC5D antibody [EPR28376-41]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPRC5D antibody [EPR28376-41] (AB315808)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Sample Prep & Detection Kits

AB102903

PE/Cy7® Conjugation Kit - Lightning-Link®

Conjugation - PE/Cy7® Conjugation Kit - Lightning-Link® (AB102903)

  • 0
  • 0

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