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AB289774

重组人GPCR GPR146蛋白

Recombinant Human GPCR GPR146 protein

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Recombinant Human GPCR GPR146 protein is a Human Full Length protein, in the 1 to 333 aa range, expressed in Cell free, with >90%, suitable for SDS-PAGE.

查看别名

PGR8, GPR146, G-protein coupled receptor 146, G-protein coupled receptor PGR8

1 Images
SDS-PAGE - Recombinant Human GPCR GPR146 protein (AB289774)
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Supplier Data

SDS-PAGE - Recombinant Human GPCR GPR146 protein (AB289774)

SDS-PAGE analysis of ab289774

关键信息

纯度

>90% SDS-PAGE

表达系统

Cell free

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q96CH1

不含动物源

Yes

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.79% Sodium chloride, 0.14% Disodium hydrogenorthophosphate, 0.05% 2-Octadecoxyethanol, 0.024% Potassium phosphate monobasic, 0.02% Potassium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA","proteinLength":"Full Length","predictedMolecularWeight":"37.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q96CH1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 146 commonly known as GPCR GPR146 is a member of the extensive GPCR family involved in cell signaling. It weighs approximately 42 kDa. GPR146 is located on the cell membrane mainly expressed in the brain and heart tissues. This protein like other GPCRs works by activating intracellular signal transduction pathways in response to extracellular signals.
Biological function summary

GPCR GPR146 binds with specific ligands initiating a signaling cascade that affects cellular responses. While no solid evidence indicates that GPR146 forms part of a complex it seems to interact with G proteins. This interaction stimulates secondary messenger pathways which can modulate various physiological processes.

Pathways

GPR146 is implicated in the G protein signaling pathway influencing processes like neurotransmission and cardiovascular regulation. It maintains connections with other proteins in these pathways such as G proteins and adenylate cyclases which are important for propagating signal transduction events within the cell ultimately influencing cellular responses.

GPCR GPR146 has been linked to atherosclerosis and cardiovascular diseases. Alterations in GPCR GPR146 could disrupt normal signal transduction contributing to these conditions. It shows relations to other proteins involved in these disorders such as LDL receptors which highlights its significance in lipid metabolism and cardiovascular health.
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特殊说明

形式

Lyophilized

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常规信息

功能

G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).

序列相似性

Belongs to the G-protein coupled receptor 1 family.

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产品实验方案

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靶点信息

G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).
See full target information GPR146
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搭配使用产品

Reagents, Controls & Accessories

AB325995

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands) (AB325995)

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Proteins & Peptides

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SDS-PAGE - Recombinant Human GPCR GPR39 protein (GST tag N-Terminus) (AB152435)

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Proteins & Peptides

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SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Proteins & Peptides

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Recombinant Human GPCR GPR85 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR85 protein (GST tag N-Terminus) (AB162723)

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