AB153211

重组人GP210蛋白

Name: 重组人GP210蛋白 (ab153211)| Abcam中文官网
Brand: Abcam Limited
SKU: AB153211
Price: 6810 CNY
Availability: InStock

Recombinant Human GP210 protein

Be the first to review this product! Submit a review

(0 Publication)

Recombinant Human GP210 protein is a Human Full Length protein, in the 1 to 967 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

KIAA0906, PSEC0245, NUP210, Nuclear pore membrane glycoprotein 210, Nuclear pore protein gp210, Nuclear envelope pore membrane protein POM 210, Nucleoporin Nup210, Pore membrane protein of 210 kDa, POM210

1 Images

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

ab153211 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

WB, ELISA

applications

生物活性

访问

Q8TEM1

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

style

left-column

style

left-column

序列信息

[{"sequence":"MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVLETGRLYEITIEVFDKFSNKVYVSDNIRIETVLPAEFFEVLSSSQNGSYHRIRALKRGQTAIDAALTSVVDQDGGVHILQVPVWNQQEVEIHIPITLYPSILTFPWQPKTGAYQYTIRAHGGSGNFSWSSSSHLVATVTVKGVMTTGSDIGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEFAPCQVEARVGQALELPLRISGLMPGGASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPPGSEHCSGIRVKAEAQGSTTLLVSYRHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSKEMLFEGGPRPWILEPSKFFQNVTAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVIALSVGNKPSLTNPFPAVEPAVVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVSSHRNPRLDLAAYDQEGRRFDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLHGLQAILVHEASGTTAITATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPEEVTIYNHPGIQAELRIREGSGYFFLNTSTADVVKVAYQEARGVAMVSLGHRSPLLVFIPYLGCCVVN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":967,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TEM1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

style

left-column

性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GP210 also known as Nup210 is a critical component of the nuclear pore complex with a molecular mass of approximately 210 kDa. This integral membrane protein is primarily expressed in the nuclear envelope of eukaryotic cells. GP210 plays a significant mechanical role in the structural integrity of the nuclear pore complex a pivotal gateway for nucleocytoplasmic transport. Its localization at the nuclear envelope suggests its importance in maintaining the selective barrier and facilitating transport functions between the nucleus and the cytoplasm.

Biological function summary

GP210 is involved in the regulation of nuclear-cytoplasmic transport and acts as a scaffold for various transport machinery components. As a member of the nuclear pore complex it interacts with other nucleoporins forming a channel that allows the passage of molecules between the nucleus and cytoplasm. GP210 participates in processes related to genome regulation influencing gene expression by modulating nuclear import/export cycles. Alterations in GP210 function can have implications for the cell cycle and differentiation processes.

Pathways

GP210 engages in the nucleocytoplasmic transport pathway which is essential for the transport of macromolecules such as RNA and proteins. This pathway is closely related to the Ran GTPase cycle where GP210 plays a supporting role in maintaining the directionality of the transport. It interacts with transport factors such as importins and exportins ensuring the precise regulation of molecular traffic. GP210's involvement ties it to key cellular functions and highlights its critical role in cellular homeostasis and signal transduction.

Aberrant function or expression of GP210 has been implicated in autoimmune diseases such as primary biliary cholangitis (PBC). Autoantibodies against GP210 are often detected in patients with PBC indicating its role in the pathogenesis of this autoimmune liver disorder. Furthermore GP210 is associated with certain cancer types where its dysregulation might contribute to tumorigenesis and cancer progression. In these contexts GP210 could interact with oncogenic or tumor suppressor proteins highlighting its potential as a biomarker and target for therapeutic intervention.

style

left-column

特殊说明

形式

Liquid

style

left-column

常规信息

功能

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

序列相似性

Belongs to the NUP210 family.

翻译后修饰

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).. Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.

亚细胞定位

Nucleus

style

left-column

产品实验方案

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

See full target information NUP210

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组人GP210蛋白

Recombinant Human GP210 protein

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液