重组人GNB1蛋白
Recombinant Human GNB1 protein
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Recombinant Human GNB1 protein is a Human Full Length protein, in the 1 to 340 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
查看别名
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Transducin beta chain 1, GNB1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GNB1 protein (AB132818)
12.5% SDS-PAGE analysis of ab132818 stained with Coomassie Blue.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
G-protein signaling inhibitors rely on the interaction of GNB1 within the cellular framework. GNB1 is part of a larger protein complex called heterotrimeric G-proteins. This complex includes three subunits: alpha beta and gamma where GNB1 typically partners with the gamma subunit to stabilize and enhance signal transduction. GNB1 modulates diverse biological processes by enabling proper functioning of neurotransmitter and hormone receptors.
Pathways
GNB1 plays a role in the GPCR (G-protein-coupled receptor) signaling pathway which is one of the largest and most varied signal transduction pathways. Additionally GNB1 influences the MAPK signaling pathway which is important for regulating processes such as cell proliferation and differentiation. In these pathways GNB1 interacts closely with various proteins such as G-alpha subunits and mitogen-activated proteins ensuring precise and targeted signaling outcomes.
特殊说明
形式
Liquid
常规信息
功能
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed : 29925951, PubMed : 33762731, PubMed : 34239069, PubMed : 35610220, PubMed : 35714614, PubMed : 35835867, PubMed : 36087581, PubMed : 36989299, PubMed : 37327704, PubMed : 37935376, PubMed : 37935377, PubMed : 37963465, PubMed : 37991948, PubMed : 38168118, PubMed : 38552625). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (PubMed : 29925951, PubMed : 33762731, PubMed : 34239069, PubMed : 35610220, PubMed : 35714614, PubMed : 35835867, PubMed : 36087581, PubMed : 36989299, PubMed : 37327704, PubMed : 37935376, PubMed : 37935377, PubMed : 37963465, PubMed : 38168118, PubMed : 38552625).
序列相似性
Belongs to the WD repeat G protein beta family.
翻译后修饰
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.
靶点信息
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