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AB123163

重组人GMPR1蛋白

Recombinant Human GMPR1 protein

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Recombinant Human GMPR1 protein is a Human Full Length protein, in the 1 to 345 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

GMPR1, GMPR, GMP reductase 1, GMPR 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1

1 Images
SDS-PAGE - Recombinant Human GMPR1 protein (AB123163)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GMPR1 protein (AB123163)

15% SDS-PAGE analysis of ab123163 (3 µg).

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

P36959

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMPRIDADLKLDFKDVLLRPKRSSLKSRAEVDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQHSMFTAIHKHYSLDDWKLFATNHPECLQNVAVSSGSGQNDLEKMTSILEAVPQVKFICLDVANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRTKTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTECAGEVIERNGRKLKLFYGMSSDTAMNKHAGGVAEYRASEGKTVEVPYKGDVENTILDILGGLRSTCTYVGAAKLKELSRRATFIRVTQQHNTVFS","proteinLength":"Full Length","predictedMolecularWeight":"39.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":345,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P36959","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The GMPR1 protein also known as guanosine monophosphate reductase 1 acts mechanistically as an enzyme that catalyzes the conversion of guanosine monophosphate (GMP) to inosine monophosphate (IMP). This reaction is part of the purine nucleotide cycle important for maintaining the balance of nucleotide pools in cells. GMPR1 has a molecular mass of approximately 37 kDa. Expression of GMPR1 is detected in various tissues with significant levels present in liver and kidney tissues.
Biological function summary

GMPR1 plays a critical role in purine metabolism by regulating the intracellular concentrations of guanine nucleotides. It does not work as part of a larger complex but functions independently to achieve its effects on nucleotide turnover. This protein ensures efficient recycling of guanine nucleotides which is important for cellular processes such as DNA and RNA synthesis signalling and energy metabolism.

Pathways

GMPR1 is involved mainly in the purine salvage pathway and the nucleotide degradation pathway. Through these pathways GMPR1 links with other proteins like hypoxanthine-guanine phosphoribosyltransferase (HGPRT) which also participates in nucleotide salvage. The balance achieved in these pathways is essential for cellular proliferation and energy conservation highlighting GMPR1's role in overall cellular homeostasis.

GMPR1 has connections to conditions like gout and certain types of cancer where there is an imbalance in purine metabolism. The misregulation of GMPR1 potentially affecting the pathways it participates in may lead to excess uric acid production seen in gout or altered nucleotide metabolism in tumorigenesis. Additionally proteins such as HGPRT which interacts within the same purine pathways also exhibit associations with these disorders further illustrating the significant impact of purine metabolism in human health.
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特殊说明

形式

Liquid

附加说明

ab123163 is purified using conventional chromatography techniques.

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常规信息

功能

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

序列相似性

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

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产品实验方案

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靶点信息

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
See full target information GMPR
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