重组人Glutaminyl cyclase蛋白(His tag)
Recombinant Human Glutaminyl cyclase protein (His tag)
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Recombinant Human Glutaminyl cyclase protein (His tag) is a Human Full Length protein, in the 29 to 361 aa range, expressed in Insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
查看别名
Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, Glutaminyl-tRNA cyclotransferase, Glutamyl cyclase, QC, sQC, EC, QPCT
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Glutaminyl cyclase protein (His tag) (AB206806)
15% SDS-PAGE analysis of ab206806 (3μg).
反应性数据
产品详情
序列信息
性能和储存信息
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This enzyme modifies peptide hormones and neuropeptides by enhancing their activity or stability. Glutaminyl cyclase does not usually operate within large protein complexes. However its activity is critical for processing secretory proteins into their mature forms. Modifications by the enzyme often regulate peptide function making it an important player in cellular communication processes.
Pathways
Glutaminyl cyclase plays an important role in the neuroendocrine cascade and protein maturation pathways. This enzyme's activity connects with other proteins like hormone receptors affecting their downstream signaling processes. It also shares connections with proteins involved in the proteolytic processing pathway ensuring maturation and activation of peptide substrates.
特殊说明
形式
Liquid
附加说明
Affinity purified
常规信息
功能
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
序列相似性
Belongs to the glutaminyl-peptide cyclotransferase family.
靶点信息
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