JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB109939

重组人 GLOD4 蛋白 (His tag N-Terminus)

Recombinant Human GLOD4 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GLOD4 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 298 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

C17orf25, CGI-150, My027, GLOD4, Glyoxalase domain-containing protein 4

1 Images
SDS-PAGE - Recombinant Human GLOD4 protein (His tag N-Terminus) (AB109939)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GLOD4 protein (His tag N-Terminus) (AB109939)

15% SDS-PAGE analysis of 3μg ab109939.

关键信息

纯度

>95% SDS-PAGE

ab109939 was purified using conventional chromatography.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q9HC38

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

搭配使用产品

Primary Antibodies

AB242089

Anti-GLOD4 antibody

Immunoprecipitation - Anti-GLOD4 antibody (AB242089)

  • 0
  • 0
Proteins & Peptides

AB86987

Recombinant Human Glutaredoxin 1 protein (Tag Free)

Western blot - Recombinant Human Glutaredoxin 1 protein (Tag Free) (AB86987)

  • 0
  • 0
Primary Antibodies

AB319159

Anti-Glutaredoxin 1 antibody [EPR29206-50] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutaredoxin 1 antibody [EPR29206-50] - BSA and Azide free (AB319159)

  • 0
  • 0
Proteins & Peptides

AB106873

Recombinant Human NPL protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NPL protein (His tag N-Terminus) (AB106873)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAARRALHFVFKVGNRFQTARFYRDVLGMKVLRHEEFEEGCKAACNGPYDGKWSKTMVGFGPEDDHFVAELTYNYGVGDYKLGNDFMGITLASSQAVSNARKLEWPLTEVAEGVFETEAPGGYKFYLQNRSLPQSDPVLKVTLAVSDLQKSLNYWCNLLGMKIYEKDEEKQRALLGYADNQCKLELQGVKGGVDHAAAFGRIAFSCPQKELPDLEDLMKRENQKILTPLVSLDTPGKATVQVVILADPDGHEICFVGDEAFRELSKMDPEGSKLLDDAMAADKSDEWFAKHNKPKASG","proteinLength":"Full Length","predictedMolecularWeight":"35.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":298,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HC38","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GLOD4 also known as Glyoxalase Domain Containing 4 is a protein with a significant role in cellular processes. It has a molecular mass of approximately 18 kDa. This protein expresses mainly in the liver brain and kidneys indicating its involvement in multiple organ systems. GLOD4 contains characteristic glyoxalase domains which facilitate its biochemical actions. Studies suggest that GLOD4 structurally participates in stress response and detoxification pathways due to these domain properties.
Biological function summary

Glyoxalase Domain Containing 4 plays important roles in the detoxification of methylglyoxal a byproduct of glycolysis that can be harmful at high levels. GLOD4 does not function alone; it acts as part of the glyoxalase system which includes other Gly and Gly-related enzymes to efficiently convert toxic metabolites into non-toxic substances. Its enzymatic actions support the maintenance of cellular homeostasis and protection against glycation end-products that are damaging to cellular structures.

Pathways

Glyoxalase Domain Containing 4 operates within key metabolic routes like the glycolytic pathway and the detoxification pathway. It collaborates with enzymes like Glyoxalase I and Glyoxalase II in the aforementioned glyoxalase system to perform its roles. The action within these pathways helps reduce oxidative stress aiding in the prevention of cellular damage. GLOD4’s interaction with these enzymes and pathways highlights its importance in maintaining cellular integrity under physiological and stress conditions.

Elevated Glyoxalase Domain Containing 4 expression links to conditions such as diabetes and neurodegenerative disorders. Changes in GLOD4 levels often correspond with disruptions in methylglyoxal metabolism and oxidative stress common in these diseases. Studies also indicate relationships among GLOD4 insulin signaling and proteins such as Glyoxalase I suggesting a connection to the metabolic disturbances found in diabetes. GLOD4's involvement in detoxification pathways also affects the pathogenesis of neurodegenerative diseases potentially influencing cell survival and neuroprotection mechanisms.
style
left-column

常规信息

序列相似性

Belongs to the glyoxalase I family.

style
left-column

产品实验方案

style
left-column

靶点信息

See full target information GLOD4
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com