AB102019

重组人 GLO2 蛋白 (His tag N-Terminus)

Name: 重组人GLO2蛋白 (ab102019)| Abcam中文官网
Brand: Abcam Limited
SKU: AB102019
Price: 4892 CNY
Availability: InStock

Recombinant Human GLO2 protein (His tag N-Terminus)

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Recombinant Human GLO2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 260 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

查看别名

GLO2, HAGH1, HAGH, Glyoxalase II, Glx II

1 Images

SDS-PAGE - Recombinant Human GLO2 protein (AB102019)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GLO2 protein (AB102019)

15% SDS-PAGE analysis of 3 μg ab102019.

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

应用

Mass Spec, SDS-PAGE

applications

生物活性

访问

Q16775

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8.5 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

This product was previously labelled as HAGH

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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD","proteinLength":"Full Length","predictedMolecularWeight":"31.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":260,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16775","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Glyoxalase 2 also known as GLO2 is an important enzyme in the glyoxalase system. The protein's molecular mass is approximately 29 kDa. It catalyzes the conversion of S-D-lactoylglutathione to glutathione and D-lactic acid allowing the detoxification of methylglyoxal a byproduct of glycolysis. GLO2 is expressed in many tissues with higher levels in liver and kidney reflecting its importance in detoxifying processes.

Biological function summary

Glyoxalase 2 has a significant role in cellular detoxification and maintenance of redox balance. As part of the glyoxalase system it closely works with another enzyme glyoxalase 1 to detoxify methylglyoxal. Through this interaction GLO2 helps prevent harmful effects caused by excessive levels of advanced glycation end-products (AGEs) protecting cells from potential damage.

Pathways

Glyoxalase 2 is involved in the methylglyoxal degradation pathway within the cellular glucose metabolism process. Specifically it partners with glyoxalase 1 in this detoxification route. Additionally GLO2 contributes to glutathione metabolism where it plays a critical part alongside glutathione peroxidases which further regulate oxidative stress.

GLO2 is associated with diabetes and neurodegenerative diseases. Altered levels of glyoxalase 2 impact methylglyoxal levels and have implications in diabetic complications through protein glycation. Furthermore studies indicate its potential link with Alzheimer's disease where oxidative stress and AGEs accumulation play central roles. GLO2's connection with glyoxalase 1 remains significant as both participate in these pathological states.

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特殊说明

形式

Liquid

附加说明

ab102019 was purified using conventional chromatography.

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常规信息

功能

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

序列相似性

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

亚细胞定位

Mitochondrion matrix

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

See full target information HAGH

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重组人 GLO2 蛋白 (His tag N-Terminus)

Recombinant Human GLO2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GLO2 protein (AB102019)

关键信息

纯度

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液