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AB134597

重组人GilZ / TilZ蛋白

Recombinant Human GilZ / TilZ protein

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Recombinant Human GilZ / TilZ protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

查看别名

DSIPI, GILZ, TSC22D3, TSC22 domain family protein 3, DSIP-immunoreactive peptide, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, TSC-22-like protein, TSC-22-related protein, Protein DIP, hDIP, TSC-22R

1 Images
SDS-PAGE - Recombinant Human GilZ / TilZ protein (AB134597)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GilZ / TilZ protein (AB134597)

15% SDS-PAGE analysis of 3 μg ab134597

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q99576

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV","proteinLength":"Full Length","predictedMolecularWeight":"17.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":134,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99576","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

GilZ also known as glucocorticoid-induced leucine zipper is a protein with a mass of approximately 14 kDa. This protein acts mechanically as a transcriptional regulator and plays an important role in modulating immune cell functions. GilZ is widely expressed especially in lymphoid tissues and in cells involved in the immune response. It is also expressed in various other tissues including the brain and liver where it contributes to different cellular processes. This protein is linked to the suppression of certain inflammatory responses mediated by its interactions with key transcription factors.
Biological function summary

GilZ influences immune cell proliferation and differentiation impacting how the body responds to inflammation. It frequently forms complexes with other proteins to perform its functions. GilZ serves as a mediator of glucocorticoid actions which affects the expression of cytokines and other inflammatory mediators. Through its interactions with components of the immune system GilZ plays an important role in maintaining homeostasis under stress conditions such as during an inflammatory response or cell damage.

Pathways

The glucocorticoid pathway is central to the activities of GilZ. This pathway involves a complex network where GilZ interacts with proteins such as the NF-kB which is another transcription factor involved in the inflammatory response. GilZ affects this pathway by inhibiting the activity of NF-kB leading to decreased expression of pro-inflammatory cytokines. Additionally GilZ is involved in the T-cell receptor (TCR) signaling pathway where it modulates T-cell activation and survival affecting immune system regulation.

GilZ is relevant to conditions characterized by chronic inflammation such as rheumatoid arthritis and asthma. In these diseases the protein's ability to downregulate inflammation makes it a potential target for therapeutic intervention. GilZ influences the expression and activity of proteins like cytokines which are heavily involved in the inflammatory pathways of these diseases. Understanding the role of GilZ in these contexts could aid in designing more effective treatments for inflammatory conditions.
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特殊说明

形式

Liquid

附加说明

ab134597 is purified using conventional chromatography techniques.

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常规信息

功能

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed : 15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed : 12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed : 11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity).. Isoform 1. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.

序列相似性

Belongs to the TSC-22/Dip/Bun family.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed : 15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed : 12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed : 11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity).. Isoform 1. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
See full target information TSC22D3
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Complementary Products

Primary Antibodies

AB197987

Anti-GilZ / TilZ antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GilZ / TilZ antibody (AB197987)

  • 0
  • 0
Primary Antibodies

AB118418

Anti-INPP5A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-INPP5A antibody (AB118418)

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Primary Antibodies

AB126880

Anti-ZNF652 antibody

Western blot - Anti-ZNF652 antibody (AB126880)

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Primary Antibodies

AB84888

Anti-WDFY3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDFY3 antibody (AB84888)

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