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AB225652

重组人GCKR蛋白(Tagged)

Recombinant Human GCKR protein (Tagged)

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Recombinant Human GCKR protein (Tagged) is a Human Full Length protein, in the 1 to 625 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

Glucokinase regulatory protein, GKRP, Glucokinase regulator, GCKR

1 Images
SDS-PAGE - Recombinant Human GCKR protein (Tagged) (AB225652)
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Supplier Data

SDS-PAGE - Recombinant Human GCKR protein (Tagged) (AB225652)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225652 with 5% enrichment gel and 15% separation gel.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

6x His tag N-Terminus SUMO tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q14397

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB325994

Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color) (AB325994)

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Proteins & Peptides

AB225651

Recombinant Human Aquaporin 4 protein (Tagged)

SDS-PAGE - Recombinant Human Aquaporin 4 protein (Tagged) (AB225651)

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Assay Kits

AB273303

Glucokinase Activity Assay Kit (Fluorometric)

Functional Studies - Glucokinase Activity Assay Kit (Fluorometric) (AB273303)

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Primary Antibodies

AB259318

Anti-Aquaporin 4 antibody [EPR24281-65]

BOND RX™ Validated|KO Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aquaporin 4 antibody [EPR24281-65] (AB259318)

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Proteins & Peptides

AB132154

Recombinant Human Piccolo protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Piccolo protein (GST tag N-Terminus) (AB132154)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ","proteinLength":"Full Length","predictedMolecularWeight":"84.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":625,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14397","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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常规信息

功能

Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed : 23621087, PubMed : 23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed : 10456334). The affinity of GCKR for GCK is modulated by fructose metabolites : GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed : 23621087, PubMed : 23733961).

序列相似性

Belongs to the GCKR family.

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产品实验方案

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靶点信息

Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed : 23621087, PubMed : 23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed : 10456334). The affinity of GCKR for GCK is modulated by fructose metabolites : GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed : 23621087, PubMed : 23733961).
See full target information GCKR
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