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AB131810

重组人GAS 6蛋白

Recombinant Human GAS 6 protein

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Recombinant Human GAS 6 protein is a Human Full Length protein, in the 1 to 678 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

AXLLG, GAS6, Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand

1 Images
SDS-PAGE - Recombinant Human GAS 6 protein (AB131810)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GAS 6 protein (AB131810)

12.5% SDS-PAGE analysis of ab131810 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, SDS-PAGE, ELISA

applications

生物活性

No

访问

Q14393

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA","proteinLength":"Full Length","predictedMolecularWeight":"101.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":678,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q14393","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The protein Gas6 also known as growth arrest-specific 6 weighs approximately 75 kDa and functions mechanically as a ligand for the TAM (Tyro3 Axl and Mer) receptor tyrosine kinases. Gas6 protein facilitates cell signaling by binding especially to AXL receptor initiating various downstream cellular responses. It is widely expressed in different tissues including the nervous system cardiovascular system and kidneys. Additionally its expression increases in response to cellular stress and inflammatory stimuli.
Biological function summary

Gas6 influences several cellular processes such as cell survival proliferation and migration. Gas6 exerts its effects in a complex with AXL receptor which is part of a larger network involving other TAM receptors. By activating AXL Gas6 modulates immune responses inflammation and tissue repair. The protein also plays a significant role in phagocytosis helping remove apoptotic cells thereby maintaining tissue homeostasis.

Pathways

The Gas6 protein is significantly engaged in the PI3K/AKT signaling pathway important for promoting cell survival and inhibiting apoptosis. Additionally Gas6 interacts with the NF-kB pathway which regulates inflammation and immune responses. Both pathways highlight the synergy between Gas6 and AXL emphasizing their contribution to cellular integrity and response to injury.

Gas6's dysregulation associates with cancer and atherosclerosis. In oncogenesis altered Gas6-AXL signaling promotes tumor progression and resistance to therapy implicating it in diverse cancers. Meanwhile in cardiovascular diseases elevated Gas6 levels correlate with atherosclerosis interacting with inflammatory proteins such as interleukins. Understanding Gas6's role in these conditions offers potential for therapeutic targeting and biomarker development.
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特殊说明

形式

Liquid

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常规信息

功能

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed : 21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed : 23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed : 21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed : 17005688).

翻译后修饰

Isoform 2. Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

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产品实验方案

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靶点信息

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed : 21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed : 23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed : 21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed : 17005688).
See full target information GAS6
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