Recombinant Human FXI Protein Standard
Recombinant Human FXI Protein Standard
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Recombinant Human FXI Protein Standard ab327829 is a Human Full length protein expressed in HEK 293 cells suitable for SDS-PAGE, sELISA.
- Domain: Apple 1, Apple 2, Apple 3, Apple 4, Peptidase S1
- Localization: Extracellular
- Proximate region: Full length
- Tag free
- >80% SDS-PAGE
查看别名
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11
- SDS-PAGE
Lab
SDS-PAGE - Recombinant Human FXI Protein Standard (AB327829)
SDS-PAGE analysis of ab327829 under reducing conditions for 2ug protein.
反应性数据
产品详情
While the standard is the same as the one provided in the corresponding SimpleStep ELISA Kit, it cannot be treated as the consumable provided with our SimpleStep ELISA Kit due to differences in its concentration calibration.
Abcam guarantee that this protein standard is suitable for use in a sandwich ELISA. Individual results may vary due to differences in technique, laboratory equipment, buffers, and other experimental factors. The detection range provided for this protein standard is based on initial sandwich ELISA validation data.
The protein concentration is the concentration after validation on our sandwich ELISA platform. This Standard protein is guaranteed to work with our Capture and Detector antibodies in sELISA. Please contact our Scientific Supportteam to know which antibody pair is suitable for this protein.
序列信息
性能和储存信息
形式
纯化工艺
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
常规信息
功能
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
序列相似性
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
翻译后修饰
N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. Activated by F12 (activated); the presence of negatively charged surfaces accelerates activation (PubMed:2019570, PubMed:8427954). Activated by F2 (thrombin); the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, strongly accelerates activation (PubMed:2019570, PubMed:21976677). Autoactivated; the presence of negatively charged surfaces, such as polyphosphate and dextran sulfate, accelerates autoactivation and autolysis (PubMed:2019570, PubMed:21976677).
靶点信息
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