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AB271524

重组人 Frizzled 7 蛋白 (Fc tag C-Terminus)

Recombinant Human Frizzled 7 protein (Fc tag C-Terminus)

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Recombinant Human Frizzled 7 protein (Fc tag C-Terminus) is a Human Fragment protein, in the 33 to 185 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

查看别名

Frizzled-7, Fz-7, hFz7, FzE3, FZD7

1 Images
SDS-PAGE - Recombinant Human Frizzled 7 protein (Fc tag C-Terminus) (AB271524)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Frizzled 7 protein (Fc tag C-Terminus) (AB271524)

SDS-PAGE analysis of 2 μg ab271524.

This protein runs at a higher apparent MW by SDS-PAGE due to glycosylation.

关键信息

纯度

>90% SDS-PAGE

表达系统

HEK 293 cells

标签

Fc tag C-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

O75084

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.48% Tris, 0.02% Potassium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher apparent MW by SDS-PAGE due to glycosylation.</p>" } } }
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序列信息

[{"sequence":"QPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYL","proteinLength":"Fragment","predictedMolecularWeight":"43.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":185,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O75084","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Frizzled 7 also known as Frizzled receptor or Frizzled protein is a transmembrane receptor weighing approximately 75 kDa. This member of the Frizzled family acts as a receptor for Wnt proteins and plays a role in the transmission of extracellular signals to the cytoplasm. Frizzled 7 is expressed in various tissues but shows prevalent expression in organs like the intestine and kidney. The receptor's structure includes a distinctive cysteine-rich domain essential for ligand binding which sets it apart in the family of Frizzled receptors.
Biological function summary

Frizzled 7 functions in cellular processes such as regulating cell proliferation migration and differentiation. It interacts closely with Dishevelled proteins to activate downstream signaling cascades. As part of a signaling complex Frizzled 7 influences the stabilization and localization of key signaling molecules within the Wnt/β-catenin pathway. This protein's role is vital in maintaining cellular responses necessary for tissue homeostasis and development.

Pathways

Wnt/β-catenin and planar cell polarity pathways are the primary pathways involving Frizzled 7. The Wnt/β-catenin pathway sees this receptor interacting with proteins like LRP5/6 and β-catenin to regulate gene expression. Through these pathways Frizzled 7 helps balance cellular activities that ensure proper tissue growth and repair. These pathways highlight its coordination with other Frizzled receptors to bring about specific cellular responses.

Frizzled 7 has been linked to colorectal cancer and kidney diseases. Alterations in the Wnt signaling pathways where Frizzled 7 takes part can lead to uncontrolled cell proliferation contributing to tumor progression. Frizzled 7 has shown significant interactions with proteins such as APC in the development of colorectal cancer. Additionally its atypical expression levels may correlate with kidney disease progression linking it to aberrations in cellular signaling that disrupt normal kidney function. These connections highlight the receptor's potential as a therapeutic target in these disorders.
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特殊说明

形式

Liquid

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常规信息

功能

Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed : 26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.

序列相似性

Belongs to the G-protein coupled receptor Fz/Smo family.

翻译后修饰

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

亚细胞定位

Endosome membrane

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产品实验方案

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靶点信息

Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed : 26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
See full target information FZD7
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