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AB158447

重组人 FOXM1 蛋白 (GST tag N-Terminus)

Recombinant Human FOXM1 protein (GST tag N-Terminus)

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Recombinant Human FOXM1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 702 to 801 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

FKHL16, HFH11, MPP2, WIN, FOXM1, Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, HFH-11, HNF-3/fork-head homolog 11

1 Images
SDS-PAGE - Recombinant Human FOXM1 protein (GST tag N-Terminus) (AB158447)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FOXM1 protein (GST tag N-Terminus) (AB158447)

ab158447 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q08050

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

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Primary Antibodies

AB234077

Anti-FOXM1 antibody [6F11A8]

Flow Cytometry - Anti-FOXM1 antibody [6F11A8] (AB234077)

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Proteins & Peptides

AB133147

Recombinant Human FNDC5 protein

SDS-PAGE - Recombinant Human FNDC5 protein (AB133147)

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Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

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Secondary Antibodies

AB98693

Goat Anti-Mouse IgG1 (HRP) preadsorbed

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Mouse IgG1 (HRP) preadsorbed (AB98693)

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  • 1
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"LQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":801,"aminoAcidStart":702,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q08050","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Proprietary technique
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FOXM1 also known as Forkhead Box M1 functions mechanically as a transcription factor. This target plays an important role in the regulation of gene expression during the cell cycle. It is characterized by a molecular weight of approximately 85 kDa. FOXM1 is mainly expressed in actively proliferating cells including the liver lungs and thymus tissues linking it with processes involved in cellular growth and division.
Biological function summary

The transcription factor FOXM1 regulates the expression of genes important for DNA replication and mitosis. It forms part of a complex network with other proteins to initiate and sustain cell proliferation. This protein regulates key regulatory genes such as Cyclin B1 and Plk1 ensuring proper transition through various phases of the cell cycle. The presence of FOXM1 in normal tissues emphasizes its role in maintaining healthy cell division.

Pathways

FOXM1 is integral to the regulation of cell cycle pathways and interacts with proteins involved in the PI3K/AKT signaling pathway. This target coordinates with various proteins to facilitate progression through cell cycle checkpoints and modulate responses to growth signals. Proteins such as CDK1 and SKP2 operate alongside FOXM1 to advance cells from G2 phase into mitosis demonstrating its involvement in cell cycle control mechanics.

FOXM1 shows significant association with cancer progression and metastasis. Overexpression of FOXM1 has been observed in colorectal and breast cancers indicating its potential as a therapeutic target. FOXM1 interacts with proteins like β-catenin in cancerous states influencing tumor growth and survival. Mutations and dysregulation of FOXM1 contribute to oncogenic processes further underlining its role in disease development.
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常规信息

功能

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).

翻译后修饰

Phosphorylated in M (mitotic) phase (PubMed:17101782, PubMed:19160488, PubMed:30139873). Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782). Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1 (PubMed:19160488, PubMed:30139873). Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (PubMed:19160488). Phosphorylated by GSK3B leading to ubiquitination and proteasomal degradation (PubMed:26912724).. Ubiquitinated in a FBXW7-dependent manner leading to proteasomal degradation.

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产品实验方案

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靶点信息

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).
See full target information FOXM1
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