重组人FOXD3蛋白(ab134848)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Suitable for: SDS-PAGE, CellDiff
描述
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产品名称
重组人FOXD3蛋白 -
纯度
> 90 % SDS-PAGE.
ab134848 was expressed in E. coli as inclusion bodies, refolded using a temperature shift inclusion body refolding technology and chromatographically purified. -
表达系统
Escherichia coli -
Accession
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蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
29 amino acid Tag-GEFTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGC DSPAGPPEL RLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGP GGDVGAPEADGCKGGVGGEEGGASG GGPGAGSGSAGGLAPSKPKNSLV KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREK FPAWQNS IRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFK RHQQEHL REQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAY SHPAAAAAAAAAAALQYPYALPP VAPVLPPAVPLLPSGELGRKAAAFG SQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPS ARPSFSIEN IIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAALMATH QPLSL SRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQLE ESGGGGSPGRRRRRRRRRRR -
预测分子量
48 kDa -
氨基酸
2 to 478
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab134848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Cell Differentiation
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at -20°C.
pH: 8.00
Constituent: 0.32% Tris HCl
Contains a proprietary formulation of NaCl, EDTA, KCl, arginine, DTT and Glycerol.
常规信息
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别名
- AIS1
- forkhead box D3
- Forkhead box protein D3
see all -
功能
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. -
组织特异性
Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. -
疾病相关
Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1) [MIM:607836]. AIS1 is a disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). -
序列相似性
Contains 1 fork-head DNA-binding domain. -
细胞定位
Nucleus. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (1)
ab134848 被引用在 1 文献中.
- Vanzan L et al. High throughput screening identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites. Nat Commun 12:3337 (2021). PubMed: 34099689