JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB174554

重组人 FAIM1 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 213 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

FAIM1, FAIM, Fas apoptotic inhibitory molecule 1

1 Images
SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FAIM1 protein (denatured) (His tag N-Terminus) (AB174554)

15% SDS-PAGE analysis of ab174554 (3 μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q9NVQ4

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

style
left-column

搭配使用产品

Primary Antibodies

AB215191

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

  • 5
  • 4
Proteins & Peptides

AB164800

Recombinant Human TMEM116 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TMEM116 protein (GST tag N-Terminus) (AB164800)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB209845

Anti-GSDMD antibody [EPR19828]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-GSDMD antibody [EPR19828] (AB209845)

  • 4
  • 3
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKMTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS","proteinLength":"Full Length","predictedMolecularWeight":"26.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":213,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NVQ4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FAIM1 also known as Fas Apoptotic Inhibitory Molecule 1 inhibits apoptosis. This protein has a molecular mass of approximately 24 kDa and comes from expression in various tissues with significant presence in the brain liver and immune cells. FAIM1 blocks apoptotic signals triggered via the Fas receptor also called CD95 ensuring cell survival under certain challenging conditions.
Biological function summary

Functions of FAIM1 support anti-apoptotic activities independent of death receptor pathways. It participates in cellular responses to stress like oxidative stress. The protein does not seem to form a complex but interacts with proteins involved in cell death regulation such as Fas-associated proteins to modulate stress response and survival signaling pathways.

Pathways

FAIM1 shows involvement in apoptosis-related pathways and affects the NF-κB signaling. The protein acts in the molecular framework by inhibiting signals from the Fas receptor collaborating with proteins such as FLIP which also regulate cell death pathways. FAIM1 further influences signaling through NF-κB essential in modulating the immune response.

Research links FAIM1 to neurodegenerative diseases like Alzheimer's disease due to its protective effects against apoptotic cell death. Connections exist between FAIM1 and increased cell survival involving proteins like Bcl-xL which enhance the survival of neurons in stressful environments. FAIM1 also associates with cancer where its overexpression could relate to increased tumor cell survival detailing interactions with oncogenic pathways.
style
left-column

常规信息

功能

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.

序列相似性

Belongs to the FAIM1 family.

style
left-column

产品实验方案

style
left-column

靶点信息

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
See full target information FAIM
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com