AB114651

重组人 EFEMP1/Fibulin-3 蛋白 (GST tag N-Terminus)

Name: 重组人EFEMP1/Fibulin-3蛋白 (ab114651)| Abcam中文官网
Brand: Abcam Limited
SKU: AB114651
Price: 7184 CNY
Availability: InStock

Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus)

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Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 493 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

FBLN3, FBNL, EFEMP1, EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, Fibrillin-like protein, Fibulin-3, FIBL-3

1 Images

SDS-PAGE - Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus) (AB114651)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus) (AB114651)

12.5% SDS-PAGE showing ab114651 at approximately 79.97kDa stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

WB, SDS-PAGE, ELISA

applications

生物活性

访问

Q12805

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"(Recombinant protein)." } } }

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产品详情

This product was previously labelled as EFEMP1.

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序列信息

[{"sequence":"MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVGQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGSENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTASSIGTFRTSSVLRLTIIVGPFSF","proteinLength":"Full Length","predictedMolecularWeight":"79.97 kDa","actualMolecularWeight":null,"aminoAcidEnd":493,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q12805","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

EFEMP1 also known as Fibulin-3 is a member of the fibulin family involved in extracellular matrix (ECM) organization. The protein's mass is approximately 55 kDa. It is expressed in various tissues but researchers find it most common in the eye lung and arterial walls. As a secreted glycoprotein Fibulin-3 plays a vital role in maintaining structural integrity and elasticity in connective tissues.

Biological function summary

EFEMP1/Fibulin-3 participates in ECM modulation and cell signaling. It interacts with other ECM components such as fibronectin and collagen contributing to structural assembly and stability. Although not prominently part of multi-protein complexes Fibulin-3 influences cellular adhesion and migration impacting tissue development and repair mechanisms. Researchers observe its expression during embryogenesis suggesting a role in developmental processes.

Pathways

EFEMP1/Fibulin-3 integrates into matrix-related pathways impacting tissue architecture. It plays a role in the EGF (Epidermal Growth Factor) signaling pathway which is important for various cell survival and proliferation processes. Fibulin-3 exhibits functional relationships with proteins like fibronectin and integrins within these pathways highlighting its importance in mediating cell-matrix interactions and influencing signal transduction cascades.

EFEMP1/Fibulin-3 has notable connections with certain pathologies. Malfunctions in its expression or structure can relate to age-related macular degeneration and various forms of cancer including mesothelioma. In these diseases Fibulin-3 interacts with proteins such as matrix metalloproteinases which degrade extracellular matrix proteins thereby influencing tumor progression and ECM remodeling in affected tissues.

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特殊说明

形式

Liquid

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常规信息

功能

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

序列相似性

Belongs to the fibulin family.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information EFEMP1

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重组人 EFEMP1/Fibulin-3 蛋白 (GST tag N-Terminus)

Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human EFEMP1/Fibulin-3 protein (GST tag N-Terminus) (AB114651)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液