重组人Dub3蛋白
Recombinant Human Dub3 protein
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Recombinant Human Dub3 protein is a Human Fragment protein, in the 431 to 530 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
查看别名
DUB3, USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M, USP17L2, Ubiquitin carboxyl-terminal hydrolase 17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, DUB-3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Dub3 protein (AB112436)
12.5% SDS-PAGE showing ab112436 at approximately 36.63kDa stained with Coomassie Blue.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Deubiquitinase 3 plays a significant role in regulating cell cycle progression and DNA damage response. It is often found within a larger complex where it interacts with other proteins to exert its function. This enzyme modulates the activity of several key proteins such as Cyclin A and Cdc25A by controlling their ubiquitination status which influences cell division and repair mechanisms in the cell. By maintaining these processes Dub3 ensures the fidelity of the cell cycle and genomic integrity.
Pathways
The function of Dub3 integrates into the ubiquitin-proteasome system and the DNA damage repair pathway. In the ubiquitin-proteasome system Dub3 removes ubiquitin chains from target proteins which determines their fate either for degradation or stabilization. On the DNA damage repair front Dub3 contributes to pathways involving proteins like p53 by deubiquitinating and stabilizing them allowing for an adequate response to DNA damage signals and maintaining cellular homeostasis.
特殊说明
形式
Liquid
常规信息
功能
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.
序列相似性
Belongs to the peptidase C19 family. USP17 subfamily.
亚细胞定位
Nucleus
靶点信息
搭配使用产品
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