AB153463

重组人DENND1A蛋白

Name: 重组人DENND1A蛋白 (ab153463)| Abcam中文官网
Brand: Abcam Limited
SKU: AB153463
Price: 6810 CNY
Availability: InStock

Recombinant Human DENND1A protein

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Recombinant Human DENND1A protein is a Human Full Length protein, in the 1 to 559 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

FAM31A, KIAA1608, DENND1A, DENN domain-containing protein 1A, Connecdenn 1, Protein FAM31A, Connecdenn

1 Images

SDS-PAGE - Recombinant Human DENND1A protein (AB153463)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DENND1A protein (AB153463)

ab153463 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

WB, ELISA

applications

生物活性

访问

Q8TEH3

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPITVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQNTIATPATLHILQKSITHFAAKFPTRGWTSSSH","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":559,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TEH3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DENND1A also known as DENN domain-containing protein 1A functions as a guanine nucleotide exchange factor (GEF) with a recognized molecular mass of approximately 115 kDa. It facilitates the activation of Rab proteins which are small GTPases involved in the regulation of intracellular vesicular transport. DENND1A is expressed in various tissues with significant levels found in the brain liver and kidneys indicating its diverse role in cellular processes.

Biological function summary

DENND1A plays an important part in regulating endocytic membrane traffic. It forms part of the multi-protein complex that is responsible for vesicle budding delivery and membrane fusion. This protein aids in mediating the interactions between vesicles and their target membranes ensuring precise and timely transport of cellular materials. Its role in cellular transport highlights the importance of maintaining cellular homeostasis and function.

Pathways

DENND1A participates significantly in the endocytic and exocytic pathways. These pathways control the internalization and secretion of cellular substances important for cellular communication and nutrient uptake. DENND1A influences the function of the Rab GTPases which play a central role in these pathways. Through this interaction DENND1A helps in maintaining the balance between vesicle trafficking and signaling pathways.

DENND1A has been linked to conditions such as polycystic ovary syndrome (PCOS) and certain neurological disorders. Its interaction with proteins involved in these diseases such as insulin receptor substrates in PCOS suggests that alterations in DENND1A expression or function could disrupt normal cellular transport and signaling mechanisms contributing to disease pathogenesis. Understanding its role in these disorders could offer insight into potential therapeutic targets.

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特殊说明

形式

Liquid

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常规信息

功能

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed : 20154091, PubMed : 20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity).

翻译后修饰

Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information DENND1A

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重组人DENND1A蛋白

Recombinant Human DENND1A protein

SDS-PAGE - Recombinant Human DENND1A protein (AB153463)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液