AB119719

重组人Cyclin E1蛋白

Name: 重组人Cyclin E1蛋白 (ab119719)| Abcam中文官网
Brand: Abcam Limited
SKU: AB119719
Price: 3852 CNY
Availability: InStock

Recombinant Human Cyclin E1 protein

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(1 Publication)

Recombinant Human Cyclin E1 protein is a Human Full Length protein, in the 1 to 410 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, WB.

查看别名

CCNE, CCNE1, G1/S-specific cyclin-E1

1 Images

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

SDS Page analysis of ab119719

关键信息

纯度

>90% SDS-PAGE

表达系统

Baculovirus infected Sf9 cells

应用

SDS-PAGE, WB

applications

生物活性

访问

P24864

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.003% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"linker":null,"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"73 kDa","actualMolecularWeight":null,"aminoAcidEnd":410,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P24864","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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特殊说明

形式

Liquid

附加说明

Purity tested by densitometry. Affinity purified.

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常规信息

功能

Essential for the control of the cell cycle at the G1/S (start) transition.

序列相似性

Belongs to the cyclin family. Cyclin E subfamily.

翻译后修饰

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.. Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Essential for the control of the cell cycle at the G1/S (start) transition.

See full target information CCNE1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 9:eadi3821 PubMed37801505

2023

LncRNA EILA promotes CDK4/6 inhibitor resistance in breast cancer by stabilizing cyclin E1 protein.

Applications

Unspecified application

Species

Unspecified reactive species

Zijie Cai,Qianfeng Shi,Yudong Li,Liang Jin,Shunying Li,Lok Lam Wong,Jingru Wang,Xiaoting Jiang,Mengdi Zhu,Jinna Lin,Qi Wang,Wang Yang,Yujie Liu,Jun Zhang,Chang Gong,Herui Yao,Yandan Yao,Qiang Liu

View all publications

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重组人Cyclin E1蛋白

Recombinant Human Cyclin E1 protein

SDS-PAGE - Recombinant Human Cyclin E1 protein (AB119719)

关键信息

纯度

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液