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AB307353

重组人CXCL2蛋白(Active)

Recombinant Human CXCL2 Protein (Active)

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Recombinant Human CXCL2 Protein (Active) is a Human Full Length protein, in the 35 to 107 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC, FuncS.

查看别名

GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha

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Functional Studies - Recombinant Human CXCL2 Protein (Active) (AB307353)
  • FuncS

Lab

Functional Studies - Recombinant Human CXCL2 Protein (Active) (AB307353)

Fully biologically active determined by dose dependent induction of cell migration/chemotaxis of BaF3 mouse pro-B cells overexpressing human CXCR2.

ED50 is ≤ 160 ng/ml, corresponding to a specific activity of 6.25 x 103 units/mg.

Mass Spectrometry - Recombinant Human CXCL2 Protein (Active) (AB307353)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Human CXCL2 Protein (Active) (AB307353)

Predicted MW is 7949.47 Da (+/- 10 Da by ESI-TOF). Observed MW is 7950.01 Da.

SDS-PAGE - Recombinant Human CXCL2 Protein (Active) (AB307353)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CXCL2 Protein (Active) (AB307353)

SDS-PAGE analysis of ab307353

HPLC - Recombinant Human CXCL2 Protein (Active) (AB307353)
  • HPLC

Supplier Data

HPLC - Recombinant Human CXCL2 Protein (Active) (AB307353)

HPLC analysis of ab307353

关键信息

纯度

>95% HPLC

SDS-PAGE >= 95%

内毒素水平

<0.005 EU/µg

表达系统

HEK 293 cells

标签

Tag free

应用

SDS-PAGE, FuncS, Mass Spec, HPLC

applications

生物活性

Yes

生物学活性

Fully biologically active determined by dose dependent induction of cell migration/chemotaxis of BaF3 mouse pro-B cells overexpressing human CXCR2.

ED50 is ≤ 160 ng/ml, corresponding to a specific activity of 6.25 x 103 units/mg.

访问

P19875

不含动物源

Yes

不含载体蛋白

No

种属

Human

复溶

Reconstitute in PBS

存储溶液

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB313995

Prestained Protein Ladder - Mid-range molecular weight (15 - 170 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (15 - 170 kDa) (AB313995)

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AB280332

Recombinant human CXCL10/IP10 protein (Active)

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Mass Spectrometry - Recombinant human CXCL10/IP10 protein (Active) (AB280332)

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Recombinant human IL-8 protein (Active)

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Functional Studies - Recombinant human IL-8 protein (Active) (AB259397)

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AB271715

Recombinant human PLA2G7 protein (Active) (His tag C-Terminus)

Functional Studies - Recombinant human PLA2G7 protein (Active) (His tag C-Terminus) (AB271715)

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Proteins & Peptides

AB283439

Recombinant Human CXCL1/GRO alpha protein

Mass Spectrometry - Recombinant Human CXCL1/GRO alpha protein (AB283439)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"APLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN","proteinLength":"Full Length","predictedMolecularWeight":"7.95 kDa","actualMolecularWeight":"7.95 kDa","aminoAcidEnd":107,"aminoAcidStart":35,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P19875","tags":[]}]
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性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
True
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.
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常规信息

功能

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.

序列相似性

Belongs to the intercrine alpha (chemokine CxC) family.

翻译后修饰

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

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产品实验方案

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靶点信息

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
See full target information CXCL2
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