重组人Contactin 6蛋白

补充信息

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Contactin 6 also known as CNTN6 is a neural cell adhesion molecule that plays an important role in the communication and interconnection of nerve cells. This protein has a molecular weight of approximately 110 kDa and belongs to the immunoglobulin superfamily. Contactin 6 is highly expressed in the central nervous system especially in the brain regions such as the cerebellum and hippocampus. It facilitates the formation of axonal connections and supports the proper functioning of neural circuits influencing synaptic stability and plasticity.

Biological function summary

Contactin 6 contributes significantly to the development and maintenance of the nervous system. This protein often interacts with other cell adhesion molecules forming complexes that mediate cell-cell interactions necessary for neuronal patterning and guidance. It regulates axon growth and helps in establishing precise neural networks. Through these connections Contactin 6 plays a role in developmental processes that affect neuronal migration and differentiation.

Pathways

Contactin 6 participates in neural development and signaling pathways. One important pathway is the cell adhesion pathway where Contactin 6 interacts with proteins like L1CAM and NrCAM essential for axonal guidance and synaptogenesis. Another pathway involves its association with the Notch signaling pathway which influences neurogenic outcomes and fate specification during embryonic development. These interactions highlight its importance in neural connectivity and signaling.

Contactin 6 has been linked to neurodevelopmental disorders and autism spectrum disorders (ASD). Alterations in CNTN6 expression or mutations might disrupt neurodevelopment and lead to cognitive impairments. The protein interacts with autism-related proteins such as CASPR2 influencing synaptic connectivity that might underpin these disorders. Furthermore some studies suggest an association with attention deficit hyperactivity disorder (ADHD) where similar pathways and protein interactions contribute to symptomatology and neurological development issues.