重组人Constitutive androstane receptor蛋白(ab83193)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% Affinity purified
- Suitable for: Functional Studies
描述
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产品名称
重组人Constitutive androstane receptor蛋白 -
生物活性
1 unit equals 1 nanogram of purified protein. -
纯度
> 90 % Affinity purified.
Recombinant ab83193 was expressed in a E.coli system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 90% homogeneous and contains no detectable protease, DNase and RNase activity. -
表达系统
Escherichia coli -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human
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技术指标
Our Abpromise guarantee covers the use of ab83193 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Functional Studies
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形式
Liquid -
补充说明
1 unit equals 1 nanogram of purified protein. -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.9
Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol (glycerin, glycerine)
常规信息
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别名
- CAR
- CAR BETA
- CAR1
see all -
功能
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. -
组织特异性
Predominantly expressed in liver. -
序列相似性
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
结构域
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. -
翻译后修饰
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. -
细胞定位
Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Recruited to the cytoplasm by DNAJC7. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab83193 尚未被引用在任何文献中。