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AB181921

重组人 CHCHD8 蛋白 (His tag N-Terminus)

Recombinant Human CHCHD8 protein (His tag N-Terminus)

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Recombinant Human CHCHD8 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 87 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

CHCHD8, E2IG2, COA4, Coiled-coil-helix-coiled-coil-helix domain-containing protein 8, E2-induced gene 2 protein

1 Images
SDS-PAGE - Recombinant Human CHCHD8 protein (His tag N-Terminus) (AB181921)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CHCHD8 protein (His tag N-Terminus) (AB181921)

15% SDS-PAGE analysis of ab181921 (3μg).

关键信息

纯度

>90% SDS-PAGE

ab181921 purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

Mass Spec, SDS-PAGE

applications

生物活性

No

访问

Q9NYJ1

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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搭配使用产品

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Recombinant Human GAS41 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GAS41 protein (His tag N-Terminus) (AB116188)

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Proteins & Peptides

AB152790

Recombinant Human FIP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human FIP protein (GST tag N-Terminus) (AB152790)

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Proteins & Peptides

AB112374

Recombinant Human Tristetraprolin/TTP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Tristetraprolin/TTP protein (GST tag N-Terminus) (AB112374)

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Proteins & Peptides

AB95933

Recombinant human XIAP protein (DDDDK tag N-Terminus)

Functional Studies - Recombinant human XIAP protein (DDDDK tag N-Terminus) (AB95933)

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  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSTSVPQGHTWTQRVKKDDEEEDPLDQLISRSGCAASHFAVQECMAQHQDWRQCQPQVQAFKDCMSEQQARRQEELQRRQEQAGAHH","proteinLength":"Full Length","predictedMolecularWeight":"12.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":87,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NYJ1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CHCHD8 is a mitochondrial protein also known as Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 8. It features a molecular mass of approximately 23 kDa. Researchers find CHCHD8 expressed predominantly in the mitochondria of skeletal muscle heart and brain tissues. This protein contributes to mitochondrial function and organization assisting in the maintenance of cellular energy and balance.
Biological function summary

CHCHD8 acts as a component of the mitochondrial intermembrane space bridging complex (MICOS). This complex plays a pivotal role in maintaining mitochondrial architecture and integrity. CHCHD8 contributes to the folding and assembly of other mitochondrial proteins. Its interactions within the MICOS complex reveal its influence on cristae morphology which is essential for the proper function of the electron transport chain.

Pathways

CHCHD8 takes part in mitochondrial biogenesis and cellular respiration pathways. These pathways are important for cell energy production and metabolic balance. CHCHD8 participates alongside proteins such as CHCHD3 and SAMM50 in regulating the structure and function of mitochondria integrating signals related to energy requirements and reactive oxygen species handling.

CHCHD8 has a connection with neuromuscular diseases and mitochondrial myopathies. Mutations or disruptions in CHCHD8 can lead to impaired mitochondrial function contributing to disease pathology. CHCHD8 is linked with CHCHD10 another protein implicated in similar disorders highlighting their combined importance in mitochondrial and neuromuscular health.
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常规信息

功能

Putative COX assembly factor.

序列相似性

Belongs to the COA4 family.

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产品实验方案

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靶点信息

Putative COX assembly factor.
See full target information COA4
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