JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB176082

重组人 CGT 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human CGT protein (denatured) (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human CGT protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 21 to 541 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

CGT, UGT4, UGT8, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase

1 Images
SDS-PAGE - Recombinant Human CGT protein (denatured) (His tag N-Terminus) (AB176082)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CGT protein (denatured) (His tag N-Terminus) (AB176082)

15% SDS-PAGE analysis of ab176082 (3μg).

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q16880

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris-HCl buffer

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

This product was previously labelled as UGT8
style
left-column

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK","proteinLength":"Full Length","predictedMolecularWeight":"61.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":541,"aminoAcidStart":21,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16880","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CGT also known as Cortactin Gene Target is a protein involved in regulating the actin cytoskeleton by binding to actin filaments. It has a molecular mass of approximately 61 kDa. CGT is highly expressed in brain tissues as well as in cells associated with the immune system. Its expression is not limited to these areas; CGT can also be found in epithelial cells and plays a role in cell movement and stability by promoting the assembly of actin structures.
Biological function summary

CGT enhances the dynamics of actin filaments influencing processes such as cell shape and motility. CGT is part of the actin cytoskeleton complex and interacts with several other proteins to stabilize actin networks. It cooperates with proteins like Arp2/3 complex to facilitate branching and elongation of actin filaments and it also participates in endocytosis and phagocytosis by modulating the actin cytoskeleton.

Pathways

The regulation of cell migration and adhesion revolves significantly around CGT's function. CGT is an important component in the pathways controlling actin remodeling particularly during cell movement and adhesion processes. Its activity is interconnected with Rac and Rho GTPases which are central to actin filament rearrangement. CGT also links with other cytoskeletal regulators like N-WASP contributing to changes in cell structure required for various cellular responses.

CGT is implicated in cancer and neurological disorders. Its role in actin filament regulation and cell motility links CGT to cancer metastasis where abnormal cell spreading is observed. In neurological disorders CGT’s regulation of synaptic organization and neuronal migration connects it to conditions involving synaptic dysfunction. In these disease contexts CGT may interact with proteins such as N-WASP and the Arp2/3 complex to alter cellular pathways and contribute to disease progression.
style
left-column

特殊说明

形式

Liquid

style
left-column

常规信息

功能

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed : 9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).

序列相似性

Belongs to the UDP-glycosyltransferase family.

style
left-column

产品实验方案

style
left-column

靶点信息

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed : 9125199). Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).
See full target information UGT8
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB174559

Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human SSSCA1 protein (denatured) (His tag N-Terminus) (AB174559)

  • 0
  • 0
Proteins & Peptides

AB177641

Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human XRCC2 protein (denatured) (His tag N-Terminus) (AB177641)

  • 0
  • 0
Proteins & Peptides

AB177632

Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ubiquinol-Cytochrome C Reductase Core Protein I (denatured) (His tag N-Terminus) (AB177632)

  • 0
  • 0
Proteins & Peptides

AB176057

Recombinant Human TRIAP1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TRIAP1 protein (His tag N-Terminus) (AB176057)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com