重组人 CETP 蛋白 (GST tag N-Terminus)

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

CETP plays a role in lipid metabolism by facilitating the redistribution of lipids among various lipoprotein particles. CETP does not function as part of a larger molecular complex but actively interacts with lipoproteins in a reversible manner. Its activity affects the levels of HDL cholesterol often referred to as "good cholesterol" and contributes to maintaining lipid levels within physiological limits. By modulating the lipid exchanges CETP influences atherosclerosis progression and cardiovascular health.

Pathways

CETP interacts significantly with lipoprotein metabolism and reverse cholesterol transport pathways. It works alongside key proteins such as apolipoprotein A-I and apolipoprotein B which are present in HDL and LDL particles respectively. CETP activity in these pathways modulates the cholesterol efflux capability of HDL affecting lipid clearance from tissues back to the liver. These interactions ensure the maintenance of cholesterol equilibrium and are vital in lipid recycling processes.