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AB162978

重组人 CEP27 蛋白 (GST tag N-Terminus)

Recombinant Human CEP27 protein (GST tag N-Terminus)

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Recombinant Human CEP27 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 235 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

C15orf25, CEP27, HAUS2, HAUS augmin-like complex subunit 2, Centrosomal protein of 27 kDa, Cep27

1 Images
SDS-PAGE - Recombinant Human CEP27 protein (GST tag N-Terminus) (AB162978)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CEP27 protein (GST tag N-Terminus) (AB162978)

ab162978 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

Q9NVX0

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MAAANPWDPASAPNGAGLVLGHFIASGMVNQEMLNMSKKTVSCFVNFTRLQQITNIQAEIYQKNLEIELLKLEKDTADVVHPFFLAQKCHTLQSMNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHLETIRNIPHLAANLKKMNQALAKMDILVTETEELAENILKWRKQQNEVSSCIPKILAEESYLYKHDIIMPPLPFTSKVHVQTINAK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":235,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NVX0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CEP27 also known as Centrosomal protein 27 or CECR2 is a protein that mechanically plays a role in centrosome function and cell cycle regulation. It has a molecular mass of approximately 28 kDa. Researchers have found CEP27 expression across various human tissues with notable levels in the brain and heart. This protein localizes in the centrosome an important cellular structure involved in microtubule organization particularly during cell division.
Biological function summary

CEP27 contributes to the maintenance of cell structure and integrity. It forms part of the centrosome complex which is essential for the proper organization of the spindle apparatus during mitosis. The coordination of CEP27 with other centrosomal proteins ensures the correct segregation of chromosomes fundamental for normal cell proliferation. Disruption of its function can lead to errors in chromosome distribution highlighting its role in genetic stability.

Pathways

Scientists have found CEP27 functions within the framework of the cell cycle regulation and mitotic spindle assembly pathways. Its interaction with proteins such as CEP192 and CEP350 reinforces its involvement in centrosome cohesion and microtubule anchoring processes. These pathways are essential for correct cell cycle progression and division indicating CEP27's critical role in cellular replication and organization.

Variations in CEP27 are associated with certain cancers including glioblastoma and breast cancer. Its interaction with proteins like NEK2 and Aurora kinase A both implicated in oncogenesis suggests that CEP27 influences tumorigenic pathways. Aberrations in expression or function may contribute to uncontrolled cell proliferation making CEP27 a potential target for therapeutic intervention in cancer research.
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特殊说明

形式

Liquid

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常规信息

功能

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

序列相似性

Belongs to the HAUS2 family.

亚细胞定位

Cytoskeleton

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产品实验方案

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靶点信息

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
See full target information HAUS2
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