AB84075

Recombinant Human CDKN2A/p16INK4a protein

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(2 Publications)

Recombinant Human CDKN2A/p16INK4a protein is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

查看别名

CDKN2, MTS1, CDKN2A, Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, p16-INK4a, CDK4I, MTS-1, p16-INK4, p16INK4A

1 Images

Sandwich ELISA - Recombinant Human CDKN2A/p16INK4a protein (AB84075)

sELISA

Unknown

Sandwich ELISA - Recombinant Human CDKN2A/p16INK4a protein (AB84075)

Standard Curve for CDKN2A/p16INK4a (Analyte : CDKN2A/p16INK4a protein (Human) (ab84075)); dilution range 1pg/ml to 1μg/ml using Capture Antibody Mouse monoclonal [DCS50.1] to CDKN2A/p16INK4a (ab16123) at 1μg/ml and Detector Antibody Rabbit polyclonal to CDKN2A/p16INK4a (ab7962) at 0.5μg/ml.

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

应用

SDS-PAGE

applications

生物活性

访问

P42771

不含动物源

不含载体蛋白

种属

Human

复溶

Reconstitute with 1x PBS, pH 8.0. to a concentration of 0.1-1.0 mg/ml.

存储溶液

Constituents: PBS, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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产品详情

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

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序列信息

[{"sequence":"MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD","proteinLength":"Full Length","predictedMolecularWeight":"16.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":156,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P42771","tags":[]}]

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性能和储存信息

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

False

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特殊说明

形式

Lyophilized

附加说明

Purity is greater than 95% by SDS-PAGE gel and HPLC analyses.

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常规信息

功能

The protein expressed by the gene CDKN2A acts as a negative regulator of normal cell proliferation by strongly interacting with CDK4 and CDK6. This interaction inhibits the ability of CDK4 and CDK6 to interact with cyclins D and to phosphorylate the retinoblastoma protein. This supplementary information is collated from multiple sources and compiled automatically.

序列相似性

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

翻译后修饰

Phosphorylation seems to increase interaction with CDK4.

亚细胞定位

Nucleus

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information CDKN2A

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Asian Pacific journal of cancer prevention : APJCP 16:5115-8 PubMed26163652

2015

The p16INK4a Antibody Immobilization Method for Immonosensor Application.

Applications

Unspecified application

Species

Unspecified reactive species

Li Yang,Xian-He Huang,Liang Sun

Asian Pacific journal of cancer prevention : APJCP 15:9375-8 PubMed25422227

2014

A piezoelectric immunosensor for early cervical cancer detection.

Applications

Unspecified application

Species

Unspecified reactive species

Li Yang,Xianhe Huang,Liang Sun

View all publications

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Recombinant Human CDKN2A/p16INK4a protein